Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium

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Fältnamn	Indikatorer	Metadata
000		04943naa a2200745 4500
001		oai:DiVA.org:umu-165961
003		SwePub
008		191205s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1659612 URI
024	7	a https://doi.org/10.1093/sleep/zsz2802 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fjell, Anders M.4 aut
245	1 0	a Self-reported sleep relates to hippocampal atrophy across the adult lifespan :b results from the Lifebrain consortium
264		c 2019-11-18
264	1	b Oxford University Press,c 2020
338		a electronic2 rdacarrier
520		a Objectives: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.Methods: Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18–90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross-sectional analyses were repeated in a sample of 21,390 participants from the UK Biobank.Results: No cross-sectional sleep—hippocampal volume relationships were found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing 0.22% greater annual loss than low scorers. The relationship between sleep and hippocampal atrophy did not vary across age. Simulations showed that the observed longitudinal effects were too small to be detected as age-interactions in the cross-sectional analyses.Conclusions: Worse self-reported sleep is associated with higher rates of hippocampal volume decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a hippocampus
653		a sleep
653		a self-report
653		a aging
653		a lifespan
653		a longitudinal
700	1	a Sørensen, Øystein4 aut
700	1	a Amlien, Inge K.4 aut
700	1	a Bartrés-Faz, David4 aut
700	1	a Bros, Didac Maciá4 aut
700	1	a Buchmann, Nikolaus4 aut
700	1	a Demuth, Ilja4 aut
700	1	a Drevon, Christian A4 aut
700	1	a Düzel, Sandra4 aut
700	1	a Ebmeier, Klaus P4 aut
700	1	a Idland, Ane-Victoria4 aut
700	1	a Kietzmann, Tim C4 aut
700	1	a Kievit, Rogier4 aut
700	1	a Kühn, Simone4 aut
700	1	a Lindenberger, Ulman4 aut
700	1	a Mowinckel, Athanasia M4 aut
700	1	a Nyberg, Lars,d 1966-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001
700	1	a Price, Darren4 aut
700	1	a Sexton, Claire E4 aut
700	1	a Solé-Padullés, Cristina4 aut
700	1	a Pudas, Sara,c Fil. Dr.d 1983-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)saatus02
700	1	a Sederevicius, Donatas4 aut
700	1	a Suri, Sana4 aut
700	1	a Wagner, Gerd4 aut
700	1	a Watne, Leiv Otto4 aut
700	1	a Westerhausen, René4 aut
700	1	a Zsoldos, Enikő4 aut
700	1	a Walhovd, Kristine B4 aut
710	2	a Umeå universitetb Umeå centrum för funktionell hjärnavbildning (UFBI)4 org
773	0	t Sleepd : Oxford University Pressg 43:5q 43:5x 0161-8105x 1550-9109
856	4	u https://doi.org/10.1093/sleep/zsz280y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1375449/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/sleep/article-pdf/43/5/zsz280/33201102/zsz280.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165961
856	4 8	u https://doi.org/10.1093/sleep/zsz280

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