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Sökning: onr:"swepub:oai:DiVA.org:umu-180055" > The Effect of Tempe...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004537naa a2200553 4500
001oai:DiVA.org:umu-180055
003SwePub
008210216s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:145236843
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1800552 URI
0247 a https://doi.org/10.1089/ther.2020.00272 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1452368432 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rass, Verena4 aut
2451 0a The Effect of Temperature Increases on Brain Tissue Oxygen Tension in Patients with Traumatic Brain Injury :b A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Substudy
264 1b Mary Ann Liebert,c 2021
338 a print2 rdacarrier
520 a Fever may aggravate secondary brain injury after traumatic brain injury (TBI). The aim of this study was to identify episodes of temperature increases through visual plot analysis and algorithm supported detection, and to describe associated patterns of changes in on brain tissue oxygen tension (PbtO2). Data derive from the high-resolution cohort of the multicenter prospective Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Temperature increases (≥0.5°C) were visually identified in 33 patients within the first 11 days of monitoring. Generalized estimating equations were used to detect significant changes of systemic and neuromonitoring parameters from baseline to the highest temperature. Patients were median 50 (interquartile range [IQR], 35–62) years old, and presented with a Glasgow Coma Scale (GCS) of 8 (IQR, 4–10). In 202 episodes of temperature increases, mean temperature rose by 1.0°C ± 0.5°C within 4 hours. Overall, PbtO2 slightly increased (ΔPbtO2 = 0.9 ± 6.1 mmHg, p = 0.022) during temperature increases. PbtO2 increased in 35% (p < 0.001), was stable in 49% (p = 0.852), and decreased in 16% (p < 0.001) of episodes. During episodes of temperature increases and simultaneous drops in PbtO2, cerebral perfusion pressure (CPP) decreased (ΔCPP −6.3 ± 11.5 mmHg; p < 0.001). Brain tissue hypoxia (PbtO2 <20 mmHg) developed during 27/164 (17%) episodes of effervescences, in the remaining 38/202 episodes baseline PbtO2 was already <20 mmHg. Comparable results were found when using algorithm-supported detection of temperature increases. In conclusion, during effervescences, PbtO2 was mostly stable or slightly increased. A decrease of PbtO2 was observed in every sixth episode, where it was associated with a decrease in CPP. Our data highlight the need for special attention to CPP monitoring and maintenance during episodes of fever.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a traumatic brain injury
653 a temperature increases
653 a brain tissue oxygen tension
653 a critical care
653 a CENTER-TBI
7001 a Huber, Lukas4 aut
7001 a Ianosi, Bogdan-Andrei4 aut
7001 a Kofler, Mario4 aut
7001 a Lindner, Anna4 aut
7001 a Picetti, Edoardo4 aut
7001 a Ortolano, Fabrizio4 aut
7001 a Beer, Ronny4 aut
7001 a Rossi, Sandra4 aut
7001 a Smielewski, Peter4 aut
7001 a Stocchetti, Nino4 aut
7001 a Helbok, Raimund4 aut
7001 a Koskinen, Lars-Owe D.,c Professor,d 1955-u Umeå universitet,Institutionen för klinisk vetenskap,CENTER-TBI HR ICU Investigators and Participants4 ctb0 (Swepub:umu)lako0002
7102 a Umeå universitetb Institutionen för klinisk vetenskap4 org
7730 t Therapeutic Hypothermia and Temperature Managementd : Mary Ann Liebertg 11:2, s. 122-131q 11:2<122-131x 2153-7658x 2153-7933
8564 u https://air.unimi.it/bitstream/2434/807286/5/1.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180055
8564 8u https://doi.org/10.1089/ther.2020.0027
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145236843

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