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Sökning: onr:"swepub:oai:DiVA.org:umu-185754" > Mixtures of persist...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
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001oai:DiVA.org:umu-185754
003SwePub
008210705s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147562105
009oai:lup.lub.lu.se:cc389eb8-7107-441c-a6e3-31dd9efaf54e
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1857542 URI
0247 a https://doi.org/10.1016/j.chemosphere.2021.1311252 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475621052 URI
0247 a https://lup.lub.lu.se/record/cc389eb8-7107-441c-a6e3-31dd9efaf54e2 URI
040 a (SwePub)umud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Björvang, Richelle D.u Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut
2451 0a Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
520 a Persistent organic pollutants (POPs) are industrial chemicals with long half-lives. Early life exposure to POPs has been associated with adverse effects. Fetal exposure is typically estimated based on concentrations in maternal serum or placenta and little is known on the actual fetal exposure. We measured the concentrations of nine organochlorine pesticides (OCPs), ten polychlorinated biphenyl (PCB) congeners, and polybrominated diphenyl ether (PBDE) congeners by gas chromatography – tandem mass spectrometry in maternal serum, placenta, and fetal tissues (adipose tissue, liver, heart, lung and brain) in 20 pregnancies that ended in stillbirth (gestational weeks 36–41). The data were combined with our earlier data on perfluoroalkyl substances (PFASs) in the same cohort (Mamsen et al. 2019). HCB, p,p’-DDE, PCB 138 and PCB 153 were quantified in all samples of maternal serum, placenta and fetal tissues. All 22 POPs were detected in all fetal adipose tissue samples, even in cases where they could not be detected in maternal serum or placenta. Tissue:serum ratios were significantly higher in later gestations, male fetuses, and pregnancies with normal placental function. OCPs showed the highest tissue:serum ratios and PFAS the lowest. The highest chemical burden was found in adipose tissue and lowest in the brain. Overall, all studied human fetuses were intrinsically exposed to mixtures of POPs. Tissue:serum ratios were significantly modified by gestational age, fetal sex and placental function. Importantly, more chemicals were detected in fetal tissues compared to maternal serum and placenta, implying that these proxy samples may provide a misleading picture of actual fetal exposures.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a Human fetal exposure
653 a Organochlorine pesticides
653 a Perfluoroalkyl substances
653 a Persistent organic pollutants
653 a Polybrominated diphenyl ether
653 a Polychlorinated biphenyls
653 a Human fetal exposure
653 a Organochlorine pesticides
653 a Perfluoroalkyl substances
653 a Persistent organic pollutants
653 a Polybrominated diphenyl ether
653 a Polychlorinated biphenyls
7001 a Vinnars, Marie-Thereseu Umeå University,Karolinska Institute,Umeå universitet,Obstetrik och gynekologi,Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Obstetrics and Gynecology Ornsköldsviks Hospital, Sweden4 aut0 (Swepub:umu)mavi0140
7001 a Papadogiannakis, Nikosu Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Gidlöf, Sebastianu Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Mamsen, Linn Saltou Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark4 aut
7001 a Mucs, Danielu Karolinska Institute4 aut
7001 a Kiviranta, Hannuu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut
7001 a Rantakokko, Panuu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut
7001 a Ruokojärvi, Päiviu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut
7001 a Lindh, Christian H.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli
7001 a Andersen, Claus Ydingu Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark4 aut
7001 a Damdimopoulou, Pauliinau Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut
7102 a Karolinska Instituteb Karolinska Institutet4 org
7730 t Chemosphered : Elsevierg 283q 283x 0045-6535x 1879-1298
8564 u https://doi.org/10.1016/j.chemosphere.2021.131125y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1577998/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.chemosphere.2021.131125
8564 u http://dx.doi.org/10.1016/j.chemosphere.2021.131125x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185754
8564 8u https://doi.org/10.1016/j.chemosphere.2021.131125
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147562105
8564 8u https://lup.lub.lu.se/record/cc389eb8-7107-441c-a6e3-31dd9efaf54e

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