Sökning: onr:"swepub:oai:DiVA.org:umu-185754" > Mixtures of persist...
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001 | oai:DiVA.org:umu-185754 | |
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008 | 210705s2021 | |||||||||||000 ||eng| | |
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024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1857542 URI |
024 | 7 | a https://doi.org/10.1016/j.chemosphere.2021.1311252 DOI |
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100 | 1 | a Björvang, Richelle D.u Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut |
245 | 1 0 | a Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses |
264 | 1 | b Elsevier,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a Persistent organic pollutants (POPs) are industrial chemicals with long half-lives. Early life exposure to POPs has been associated with adverse effects. Fetal exposure is typically estimated based on concentrations in maternal serum or placenta and little is known on the actual fetal exposure. We measured the concentrations of nine organochlorine pesticides (OCPs), ten polychlorinated biphenyl (PCB) congeners, and polybrominated diphenyl ether (PBDE) congeners by gas chromatography – tandem mass spectrometry in maternal serum, placenta, and fetal tissues (adipose tissue, liver, heart, lung and brain) in 20 pregnancies that ended in stillbirth (gestational weeks 36–41). The data were combined with our earlier data on perfluoroalkyl substances (PFASs) in the same cohort (Mamsen et al. 2019). HCB, p,p’-DDE, PCB 138 and PCB 153 were quantified in all samples of maternal serum, placenta and fetal tissues. All 22 POPs were detected in all fetal adipose tissue samples, even in cases where they could not be detected in maternal serum or placenta. Tissue:serum ratios were significantly higher in later gestations, male fetuses, and pregnancies with normal placental function. OCPs showed the highest tissue:serum ratios and PFAS the lowest. The highest chemical burden was found in adipose tissue and lowest in the brain. Overall, all studied human fetuses were intrinsically exposed to mixtures of POPs. Tissue:serum ratios were significantly modified by gestational age, fetal sex and placental function. Importantly, more chemicals were detected in fetal tissues compared to maternal serum and placenta, implying that these proxy samples may provide a misleading picture of actual fetal exposures. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
653 | a Human fetal exposure | |
653 | a Organochlorine pesticides | |
653 | a Perfluoroalkyl substances | |
653 | a Persistent organic pollutants | |
653 | a Polybrominated diphenyl ether | |
653 | a Polychlorinated biphenyls | |
653 | a Human fetal exposure | |
653 | a Organochlorine pesticides | |
653 | a Perfluoroalkyl substances | |
653 | a Persistent organic pollutants | |
653 | a Polybrominated diphenyl ether | |
653 | a Polychlorinated biphenyls | |
700 | 1 | a Vinnars, Marie-Thereseu Umeå University,Karolinska Institute,Umeå universitet,Obstetrik och gynekologi,Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Obstetrics and Gynecology Ornsköldsviks Hospital, Sweden4 aut0 (Swepub:umu)mavi0140 |
700 | 1 | a Papadogiannakis, Nikosu Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Gidlöf, Sebastianu Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Mamsen, Linn Saltou Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark4 aut |
700 | 1 | a Mucs, Danielu Karolinska Institute4 aut |
700 | 1 | a Kiviranta, Hannuu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut |
700 | 1 | a Rantakokko, Panuu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut |
700 | 1 | a Ruokojärvi, Päiviu Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare4 aut |
700 | 1 | a Lindh, Christian H.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli |
700 | 1 | a Andersen, Claus Ydingu Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark4 aut |
700 | 1 | a Damdimopoulou, Pauliinau Karolinska Institute,Karolinska Institutet,Karolinska University Hospital4 aut |
710 | 2 | a Karolinska Instituteb Karolinska Institutet4 org |
773 | 0 | t Chemosphered : Elsevierg 283q 283x 0045-6535x 1879-1298 |
856 | 4 | u https://doi.org/10.1016/j.chemosphere.2021.131125y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1577998/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.chemosphere.2021.131125 |
856 | 4 | u http://dx.doi.org/10.1016/j.chemosphere.2021.131125x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185754 |
856 | 4 8 | u https://doi.org/10.1016/j.chemosphere.2021.131125 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147562105 |
856 | 4 8 | u https://lup.lub.lu.se/record/cc389eb8-7107-441c-a6e3-31dd9efaf54e |
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