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Sökning: onr:"swepub:oai:DiVA.org:umu-22446" > Genetic variation i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005119naa a2200505 4500
001oai:DiVA.org:umu-22446
003SwePub
008090511s2009 | |||||||||||000 ||eng|
009oai:DiVA.org:mdh-40703
009oai:prod.swepub.kib.ki.se:118781478
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224462 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-08-08932 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-407032 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1187814782 URI
040 a (SwePub)umud (SwePub)mdhd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Johansson, Mattiasu Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France,Int Agcy Res Canc, F-69372 Lyon 08, France.;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Stockholm, Sweden.4 aut0 (Swepub:umu)masmas97
2451 0a Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk
264 1b AMER ASSOC CANCER RESEARCH,c 2009
338 a print2 rdacarrier
520 a BACKGROUND: Somatostatin (SST) and its receptors (SSTR1-5) may have a role in prostate cancer by influencing the IGFI hormone axis or through direct effects on prostate epithelia. We have investigated if genetic variation in the SST and SSTR1-5 genes influences prostate cancer risk and/or circulating IGFI and IGFBP3 hormone levels. MATERIALS AND METHODS: We analyzed 28 haplotype tagging single nucleotide polymorphisms in the SST and SSTR1-5 genes in a case-control/genetic association study to investigate the association between genetic variation and prostate cancer risk. The study included 2863 cases and 1737 controls from the Cancer Prostate in Sweden (CAPS) study. To investigate the genetic influence on circulating hormone levels, plasma concentrations of IGFI and IGFBP3 were analyzed in 874 controls of the CAPS study and 550 male subjects from the Northern Sweden Health and Disease Cohort (NSHDC). RESULTS: No clear association between prostate cancer risk and genetic variation of the SST and SSTR1-5 genes was identified. The SSTR5 missense single nucleotide polymorphism rs4988483 was associated with circulating IGFI (P = 0.002) and IGFBP3 (P = 0.0003) hormone levels in CAPS controls, with a per allele decrease of approximately 11%. This decrease was replicated in NSHDC for circulating IGFBP3 (P = 0.01) but not for IGFI (P = 0.09). Combining CAPS and NSHDC subjects indicated evidence of association between rs4988483 and both IGFBP3 (P = 2 x 10(-5)) and IGFI (P = 0.0004) hormone levels. CONCLUSIONS: Our results suggest that genetic variation in the SSTR5 gene and, particularly, the rs4988483 single nucleotide polymorphism influence circulating IGFI and IGFBP3 hormone levels with no measurable effect on prostate cancer risk. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1644-50).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
7001 a McKay, James Du Int Agcy Res Canc, F-69372 Lyon 08, France.4 aut
7001 a Wiklund, Fredriku Karolinska Institutet4 aut
7001 a Rinaldi, Sabinau Int Agcy Res Canc, F-69372 Lyon 08, France.4 aut
7001 a Hallmans, Göranu Umeå universitet,Näringsforskning,Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.4 aut0 (Swepub:umu)goha0001
7001 a Bälter, Katarinau Karolinska Institutet4 aut0 (Swepub:mdh)kbr01
7001 a Adami, Hans-Olovu Karolinska Institutet4 aut
7001 a Grönberg, Henriku Karolinska Institutet4 aut
7001 a Stattin, Päru Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Stockholm, Sweden.4 aut0 (Swepub:umu)past0003
7001 a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : AMER ASSOC CANCER RESEARCHg 18:5, s. 1644-1650q 18:5<1644-1650x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22446
8564 8u https://doi.org/10.1158/1055-9965.EPI-08-0893
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40703
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118781478

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