Quantification and 3-D imaging of the insulitis-induced destruction of β-cells in murine type 1 diabetes

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: onr:"swepub:oai:DiVA.org:umu-33656" > Quantification and ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Alanentalo, TomasUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Ahlgren Ulf (author)

Quantification and 3-D imaging of the insulitis-induced destruction of β-cells in murine type 1 diabetes

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-04-14
American Diabetes Association,2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-33656
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33656URI
https://doi.org/10.2337/db09-1400DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Objective: The aim of this study was to refine the information regarding the quantitative and spatial dynamics of infiltrating lymphocytes and remaining beta-cell volume during the progression of type 1 diabetes in the NOD mouse model of the disease.Research design and methods: Using an ex vivo technique, optical projection tomography (OPT), we quantified and assessed the 3D spatial development and progression of insulitis and beta-cell destruction in pancreas from diabetes prone NOD and non-diabetes prone congenic NOD.H-2b mice between 3 and 16 weeks of age.Results: Together with results showing the spatial dynamics of the insulitis process we provide data of beta-cell volume distributions down to the level of the individual islets and throughout the pancreas during the development and progression of type 1 diabetes. Our data provide evidence for a compensatory growth potential of the larger insulin(+) islets during the later stages of the disease around the time point for development of clinical diabetes. This is in contrast to smaller islets, which appear less resistant to the autoimmune attack. We also provide new information on the spatial dynamics of the insulitis process itself, including its apparently random distribution at onset, the local variations during its further development, and the formation of structures resembling tertiary lymphoid organs at later phases of insulitis progression.Conclusions: Our data provides a powerful tool for phenotypic analysis of genetic and environmental effects on type 1 diabetes etiology as well as for evaluating the potential effect of therapeutic regimes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
pancreas
mouse
mice
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Hörnblad, AndreasUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Ahlgren Ulf(Swepub:umu)anshod02 (author)
Mayans, SofiaUmeå universitet,Medicinsk och klinisk genetik,Holmberg Dan(Swepub:umu)soma0002 (author)
Nilsson, Anna KarinUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)anni0002 (author)
Sharpe, James (author)
Larefalk, ÅsaUmeå universitet,Medicinsk och klinisk genetik,Holmberg Dan(Swepub:umu)asla0002 (author)
Ahlgren, Ulf,1968-Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Ahlgren Ulf(Swepub:umu)ulah0001 (author)
Holmberg, DanUmeå universitet,Medicinsk och klinisk genetik,Holmberg Dan(Swepub:umu)daho0001 (author)
Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)

Related titles

In:Diabetes: American Diabetes Association59:7, s. 1756-17640012-17971939-327X

Internet link

Find in a library

Diabetes (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Alanentalo, Toma ...; Hörnblad, Andrea ...; Mayans, Sofia; Nilsson, Anna Ka ...; Sharpe, James; Larefalk, Åsa; show more...; Ahlgren, Ulf, 19 ...; Holmberg, Dan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Diabetes

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se