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Sökning: onr:"swepub:oai:DiVA.org:umu-42225" > Eighteen insulin-li...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005248naa a2200949 4500
001oai:DiVA.org:umu-42225
003SwePub
008110406s2010 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-422252 URI
024a https://doi.org/10.1158/1055-9965.EPI-10-05072 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Gu, Fangyi4 aut
2451 0a Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
264 1b American Association for Cancer Research,c 2010
338 a print2 rdacarrier
520 a Background: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.Methods: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 302 single nucleotide polymorphisms (SNP) were genotyped in >5,500 Caucasian men and 5,500 Caucasian women from the Breast and Prostate Cancer Cohort Consortium.Results: After adjusting for multiple testing, SNPs in the IGF1 and SSTR5 genes were significantly associated with circulating IGF-I (P < 2.1 × 10−4); SNPs in the IGFBP3 and IGFALS genes were significantly associated with circulating IGFBP-3. Multi-SNP models explained R2 = 0.62% of the variation in circulating IGF-I and 3.9% of the variation in circulating IGFBP-3. We saw no significant association between these multi-SNP predictors of circulating IGF-I or IGFBP-3 and risk of prostate or breast cancers.Conclusion: Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, and variation in IGFBP3 and IGFALS seems to influence circulating IGFBP-3. However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Impact: Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Oncology
653 a Onkologi
653 a Oncology
653 a onkologi
700a Schumacher, Fredrick R4 aut
700a Canzian, Federico4 aut
700a Allen, Naomi E4 aut
700a Albanes, Demetrius4 aut
700a Berg, Christine D4 aut
700a Berndt, Sonja I4 aut
700a Boeing, Heiner4 aut
700a Bueno-de-Mesquita, H Bas4 aut
700a Buring, Julie E4 aut
700a Chabbert-Buffet, Nathalie4 aut
700a Chanock, Stephen J4 aut
700a Clavel-Chapelon, Françoise4 aut
700a Dumeaux, Vanessa4 aut
700a Gaziano, J Michael4 aut
700a Giovannucci, Edward L4 aut
700a Haiman, Christopher A4 aut
700a Hankinson, Susan E4 aut
700a Hayes, Richard B4 aut
700a Henderson, Brian E4 aut
700a Hunter, David J4 aut
700a Hoover, Robert N4 aut
700a Johansson, Mattiasu Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
700a Key, Timothy J4 aut
700a Khaw, Kay-Tee4 aut
700a Kolonel, Laurence N4 aut
700a Lagiou, Pagona4 aut
700a Lee, I-Min4 aut
700a LeMarchand, Loic4 aut
700a Lund, Eiliv4 aut
700a Ma, Jing4 aut
700a Onland-Moret, N Charlotte4 aut
700a Overvad, Kim4 aut
700a Rodriguez, Laudina4 aut
700a Sacerdote, Carlotta4 aut
700a Sánchez, Maria-José4 aut
700a Stampfer, Meir J4 aut
700a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003
700a Stram, Daniel O4 aut
700a Thomas, Gilles4 aut
700a Thun, Michael J4 aut
700a Tjønneland, Anne4 aut
700a Trichopoulos, Dimitrios4 aut
700a Tumino, Rosario4 aut
700a Virtamo, Jarmo4 aut
700a Weinstein, Stephanie J4 aut
700a Willett, Walter C4 aut
700a Yeager, Meredith4 aut
700a Zhang, Shumin M4 aut
700a Kaaks, Rudolf4 aut
700a Riboli, Elio4 aut
700a Ziegler, Regina G4 aut
700a Kraft, Peter4 aut
710a Umeå universitetb Urologi och andrologi4 org
773t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 19:11, s. 2877-2887q 19:11<2877-2887x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42225
8564 8u https://doi.org/10.1158/1055-9965.EPI-10-0507

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