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Sökning: onr:"swepub:oai:DiVA.org:umu-42225" > Eighteen insulin-li...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005248naa a2200949 4500
001oai:DiVA.org:umu-42225
003SwePub
008110406s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-422252 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-10-05072 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gu, Fangyi4 aut
2451 0a Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
264 1b American Association for Cancer Research,c 2010
338 a print2 rdacarrier
520 a Background: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.Methods: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 302 single nucleotide polymorphisms (SNP) were genotyped in >5,500 Caucasian men and 5,500 Caucasian women from the Breast and Prostate Cancer Cohort Consortium.Results: After adjusting for multiple testing, SNPs in the IGF1 and SSTR5 genes were significantly associated with circulating IGF-I (P < 2.1 × 10−4); SNPs in the IGFBP3 and IGFALS genes were significantly associated with circulating IGFBP-3. Multi-SNP models explained R2 = 0.62% of the variation in circulating IGF-I and 3.9% of the variation in circulating IGFBP-3. We saw no significant association between these multi-SNP predictors of circulating IGF-I or IGFBP-3 and risk of prostate or breast cancers.Conclusion: Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, and variation in IGFBP3 and IGFALS seems to influence circulating IGFBP-3. However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Impact: Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Oncology
653 a Onkologi
653 a Oncology
653 a onkologi
7001 a Schumacher, Fredrick R4 aut
7001 a Canzian, Federico4 aut
7001 a Allen, Naomi E4 aut
7001 a Albanes, Demetrius4 aut
7001 a Berg, Christine D4 aut
7001 a Berndt, Sonja I4 aut
7001 a Boeing, Heiner4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a Buring, Julie E4 aut
7001 a Chabbert-Buffet, Nathalie4 aut
7001 a Chanock, Stephen J4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Dumeaux, Vanessa4 aut
7001 a Gaziano, J Michael4 aut
7001 a Giovannucci, Edward L4 aut
7001 a Haiman, Christopher A4 aut
7001 a Hankinson, Susan E4 aut
7001 a Hayes, Richard B4 aut
7001 a Henderson, Brian E4 aut
7001 a Hunter, David J4 aut
7001 a Hoover, Robert N4 aut
7001 a Johansson, Mattiasu Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
7001 a Key, Timothy J4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Kolonel, Laurence N4 aut
7001 a Lagiou, Pagona4 aut
7001 a Lee, I-Min4 aut
7001 a LeMarchand, Loic4 aut
7001 a Lund, Eiliv4 aut
7001 a Ma, Jing4 aut
7001 a Onland-Moret, N Charlotte4 aut
7001 a Overvad, Kim4 aut
7001 a Rodriguez, Laudina4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Sánchez, Maria-José4 aut
7001 a Stampfer, Meir J4 aut
7001 a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003
7001 a Stram, Daniel O4 aut
7001 a Thomas, Gilles4 aut
7001 a Thun, Michael J4 aut
7001 a Tjønneland, Anne4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Tumino, Rosario4 aut
7001 a Virtamo, Jarmo4 aut
7001 a Weinstein, Stephanie J4 aut
7001 a Willett, Walter C4 aut
7001 a Yeager, Meredith4 aut
7001 a Zhang, Shumin M4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Riboli, Elio4 aut
7001 a Ziegler, Regina G4 aut
7001 a Kraft, Peter4 aut
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 19:11, s. 2877-2887q 19:11<2877-2887x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42225
8564 8u https://doi.org/10.1158/1055-9965.EPI-10-0507

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