Sökning: onr:"swepub:oai:DiVA.org:umu-62806" > Analysis of Xq27-28...
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000 | 05959naa a2200961 4500 | |
001 | oai:DiVA.org:umu-62806 | |
003 | SwePub | |
008 | 121218s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125590654 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-628062 URI |
024 | 7 | a https://doi.org/10.1186/1471-2350-13-462 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1255906542 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bailey-Wilson, Joan E4 aut |
245 | 1 0 | a Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families |
264 | c 2012-06-19 | |
264 | 1 | a London :b BioMed Central,c 2012 |
338 | a electronic2 rdacarrier | |
520 | a Background: Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and phenotypic heterogeneity. Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive.Methods: Parametric and non-parametric linkage analyses were performed using 26 microsatellite markers in each of 11 groups of multiple-case prostate cancer families from the International Consortium for Prostate Cancer Genetics (ICPCG). Meta-analyses of the resultant family-specific linkage statistics across the entire 1,323 families and in several predefined subsets were then performed.Results: Meta-analyses of linkage statistics resulted in a maximum parametric heterogeneity lod score (HLOD) of 1.28, and an allele-sharing lod score (LOD) of 2.0 in favor of linkage to Xq27-q28 at 138 cM. In subset analyses, families with average age at onset less than 65 years exhibited a maximum HLOD of 1.8 (at 138 cM) versus a maximum regional HLOD of only 0.32 in families with average age at onset of 65 years or older. Surprisingly, the subset of families with only 2-3 affected men and some evidence of male-to-male transmission of prostate cancer gave the strongest evidence of linkage to the region (HLOD = 3.24, 134 cM). For this subset, the HLOD was slightly increased (HLOD = 3.47 at 134 cM) when families used in the original published report of linkage to Xq27-28 were excluded.Conclusions: Although there was not strong support for linkage to the Xq27-28 region in the complete set of families, the subset of families with earlier age at onset exhibited more evidence of linkage than families with later onset of disease. A subset of families with 2-3 affected individuals and with some evidence of male to male disease transmission showed stronger linkage signals. Our results suggest that the genetic basis for prostate cancer in our families is much more complex than a single susceptibility locus on the X chromosome, and that future explorations of the Xq27-28 region should focus on the subset of families identified here with the strongest evidence of linkage to this region. | |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
700 | 1 | a Childs, Erica J4 aut |
700 | 1 | a Cropp, Cheryl D4 aut |
700 | 1 | a Schaid, Daniel J4 aut |
700 | 1 | a Xu, Jianfeng4 aut |
700 | 1 | a Camp, Nicola J4 aut |
700 | 1 | a Cannon-Albright, Lisa A4 aut |
700 | 1 | a Farnham, James M4 aut |
700 | 1 | a George, Asha4 aut |
700 | 1 | a Powell, Isaac4 aut |
700 | 1 | a Carpten, John D4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Hopper, John L4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a English, Dallas R4 aut |
700 | 1 | a Foulkes, William D4 aut |
700 | 1 | a Maehle, Lovise4 aut |
700 | 1 | a Moller, Pal4 aut |
700 | 1 | a Eeles, Rosalind4 aut |
700 | 1 | a Easton, Douglas4 aut |
700 | 1 | a Guy, Michelle4 aut |
700 | 1 | a Edwards, Steve4 aut |
700 | 1 | a Badzioch, Michael D4 aut |
700 | 1 | a Whittemore, Alice S4 aut |
700 | 1 | a Oakley-Girvan, Ingrid4 aut |
700 | 1 | a Hsieh, Chih-Lin4 aut |
700 | 1 | a Dimitrov, Latchezar4 aut |
700 | 1 | a Stanford, Janet L4 aut |
700 | 1 | a Karyadi, Danielle M4 aut |
700 | 1 | a Deutsch, Kerry4 aut |
700 | 1 | a McIntosh, Laura4 aut |
700 | 1 | a Ostrander, Elaine A4 aut |
700 | 1 | a Wiley, Kathleen E4 aut |
700 | 1 | a Isaacs, Sarah D4 aut |
700 | 1 | a Walsh, Patrick C4 aut |
700 | 1 | a Thibodeau, Stephen N4 aut |
700 | 1 | a McDonnell, Shannon K4 aut |
700 | 1 | a Hebbring, Scott4 aut |
700 | 1 | a Lange, Ethan M4 aut |
700 | 1 | a Cooney, Kathleen A4 aut |
700 | 1 | a Tammela, Teuvo LJ4 aut |
700 | 1 | a Schleutker, Johanna4 aut |
700 | 1 | a Maier, Christiane4 aut |
700 | 1 | a Bochum, Sylvia4 aut |
700 | 1 | a Hoegel, Josef4 aut |
700 | 1 | a Gronberg, Henriku Karolinska Institutet4 aut |
700 | 1 | a Wiklund, Fredriku Karolinska Institutet4 aut |
700 | 1 | a Emanuelsson, Monicau Umeå universitet,Onkologi4 aut0 (Swepub:umu)moem0001 |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Valeri, Antoine4 aut |
700 | 1 | a Cussenot, Olivier4 aut |
700 | 1 | a Isaacs, William B4 aut |
710 | 2 | a Karolinska Institutetb Onkologi4 org |
773 | 0 | t BMC Medical Geneticsd London : BioMed Centralg 13, s. 46-q 13<46-x 1471-2350 |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:581082/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://bmcmedgenet.biomedcentral.com/track/pdf/10.1186/1471-2350-13-46 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-62806 |
856 | 4 8 | u https://doi.org/10.1186/1471-2350-13-46 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125590654 |
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