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Sökning: onr:"swepub:oai:DiVA.org:umu-96832" > Impact of Age and G...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004478naa a2200601 4500
001oai:DiVA.org:umu-96832
003SwePub
008141203s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-968322 URI
0247 a https://doi.org/10.1371/journal.pone.01072942 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Vishram, Julie K. K.4 aut
2451 0a Impact of Age and Gender on the Prevalence and Prognostic Importance of the Metabolic Syndrome and Its Components in Europeans. The MORGAM Prospective Cohort Project
264 c 2014-09-22
264 1b Public Library of Science (PLoS),c 2014
338 a electronic2 rdacarrier
500 a Errata PLoS ONE (2015) 10(5), e0128848 DOI: 10.1371/journal.pone.0128848
520 a Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS). Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5. Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetS*age, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS*age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05). Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Borglykke, Anders4 aut
7001 a Andreasen, Anne H.4 aut
7001 a Jeppesen, Jorgen4 aut
7001 a Ibsen, Hans4 aut
7001 a Jorgensen, Torben4 aut
7001 a Palmieri, Luigi4 aut
7001 a Giampaoli, Simona4 aut
7001 a Donfrancesco, Chiara4 aut
7001 a Kee, Frank4 aut
7001 a Mancia, Giuseppe4 aut
7001 a Cesana, Giancarlo4 aut
7001 a Kuulasmaa, Kari4 aut
7001 a Salomaa, Veikko4 aut
7001 a Sans, Susana4 aut
7001 a Ferrieres, Jean4 aut
7001 a Dallongeville, Jean4 aut
7001 a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001
7001 a Arveiler, Dominique4 aut
7001 a Wagner, Aline4 aut
7001 a Tunstall-Pedoe, Hugh4 aut
7001 a Drygas, Wojciech4 aut
7001 a Olsen, Michael H.4 aut
7102 a Umeå universitetb Kardiologi4 org
7730 t PLOS ONEd : Public Library of Science (PLoS)g 9:9, s. e107294-q 9:9<e107294-x 1932-6203
8564 u https://doi.org/10.1371/journal.pone.0107294y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:768730/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0107294&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96832
8564 8u https://doi.org/10.1371/journal.pone.0107294

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