SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-102323"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-102323" > Circulating adipone...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004528naa a2200505 4500
001oai:DiVA.org:uu-102323
003SwePub
008090506s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1023232 URI
0247 a https://doi.org/10.1159/0001274242 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Petridou, Eleni T.u Dept. of Hygiene and Epidemilogy and Pathology, University of Athens Medical School4 aut
2451 0a Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer :b two case-control studies
264 c 2008-04-17
264 1b S. Karger AG,c 2007
338 a print2 rdacarrier
520 a BACKGROUND: Decreased circulating levels of adiponectin, an adipocyte-secreted hormone and endogenous insulin sensitizer, have been associated with several obesity-related malignancies. Thiazolidinedione administration, which increases adiponectin levels, decreases risk for lung cancer. Whether circulating adiponectin levels are associated with lung cancer and/or whether adiponectin receptors are expressed in lung cancer remains unknown. METHODS: We conducted a case-control study of 85 patients with incidental, histologically confirmed lung cancer and 170 healthy controls matched by gender and age. In a separate study, archival lung specimens from 134 cancerous and 8 noncancerous tissues were examined for relative expression of adiponectin receptors AdipoR1 and AdipoR2 using immunohistochemistry. RESULTS: Tobacco smoking, heavy alcohol intake and education were all associated with lung cancer risk, whereas serum adiponectin levels were not significantly different between cases and controls (multiple logistic regression, odds ratio per SD of adiponectin among controls: 1.13, 95% confidence interval: 0.64-2.02). Adiponectin levels were significantly lower (odds ratio: 0.25, 95% confidence interval: 0.10-0.78) among patients with advanced compared to those with limited disease stage. Expression of adiponectin receptors was apparent only in the cancerous lung tissue (64.2% AdipoR1 and 61.9% AdipoR2 in cancerous vs. 0% among noncancerous tissue). Specifically, AdipoR1 was expressed in all disease types, but no difference was noted with disease stage, whereas AdipoR2 was mainly expressed in the non-small cell carcinomas and more prominently in the advanced disease stage (80%). CONCLUSIONS: Circulating adiponectin levels are not different in cases of this malignancy - which seems to be unrelated to obesity and insulin resistance - compared to their healthy controls, though hormonal levels were significantly lower in advanced versus limited lung cancer. Both adiponectin receptors were expressed in cancerous lung tissue, but not in normal control tissue and there was a differential expression by disease stage. These findings should be further explored, especially in the context of the recently reported protective effect of thiazolidinediones in diabetic patients with lung cancer.
653 a Adiponectin
653 a receptors
653 a lung cancer
653 a obesity
653 a insulin resistance
653 a thiasolidinedione
653 a MEDICINE
653 a MEDICIN
7001 a Mitsiades, Nicholasu Dept. of Hygiene and Epidemilogy and Pathology, University of Athens Medical School4 aut
7001 a Gialamas, Spyros4 aut
7001 a Angelopoulos, Miltiadis4 aut
7001 a Skalkidou, Alkistisu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)alksk607
7001 a Dessypris, Nick4 aut
7001 a Hsi, Alex4 aut
7001 a Lazaris, Nikolaos4 aut
7001 a Polyzos, Aristidis4 aut
7001 a Syrigos, Constantinos4 aut
7001 a Brennan, Aoife M.4 aut
7001 a Tseleni-Balafouta, Sofia4 aut
7001 a Mantzoros, Christos S.u Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, USA4 aut
7102 a Dept. of Hygiene and Epidemilogy and Pathology, University of Athens Medical Schoolb Institutionen för kvinnors och barns hälsa4 org
7730 t Oncologyd : S. Karger AGg 73:3-4, s. 261-269q 73:3-4<261-269x 0030-2414x 1423-0232
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102323
8564 8u https://doi.org/10.1159/000127424

Hitta via bibliotek

  • Oncology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy