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Sökning: onr:"swepub:oai:DiVA.org:uu-103503" > Investigation of th...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003713naa a2200685 4500
001oai:DiVA.org:uu-103503
003SwePub
008090519s2008 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1035032 URI
0247 a https://doi.org/10.1038/ejhg.2008.2102 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Heath, Simon C.4 aut
2451 0a Investigation of the fine structure of European populations with applications to disease association studies
264 c 2008-11-20
264 1b Springer Science and Business Media LLC,c 2008
338 a print2 rdacarrier
520 a An investigation into fine-scale European population structure was carried out using high-density genetic variation on nearly 6000 individuals originating from across Europe. The individuals were collected as control samples and were genotyped with more than 300 000 SNPs in genome-wide association studies using the Illumina Infinium platform. A major East-West gradient from Russian (Moscow) samples to Spanish samples was identified as the first principal component (PC) of the genetic diversity. The second PC identified a North-South gradient from Norway and Sweden to Romania and Spain. Variation of frequencies at markers in three separate genomic regions, surrounding LCT, HLA and HERC2, were strongly associated with this gradient. The next 18 PCs also accounted for a significant proportion of genetic diversity observed in the sample. We present a method to predict the ethnic origin of samples by comparing the sample genotypes with those from a reference set of samples of known origin. These predictions can be performed using just summary information on the known samples, and individual genotype data are not required. We discuss issues raised by these data and analyses for association studies including the matching of case-only cohorts to appropriate pre-collected control samples for genome-wide association studies.
653 a PCA
653 a GWAS
653 a European
653 a population
653 a association
653 a structure
653 a MEDICINE
653 a MEDICIN
7001 a Gut, Ivo G.4 aut
7001 a Brennan, Paul4 aut
7001 a McKay, James D.4 aut
7001 a Bencko, Vladimir4 aut
7001 a Fabianova, Eleonora4 aut
7001 a Foretova, Lenka4 aut
7001 a Georges, Michael4 aut
7001 a Janout, Vladimir4 aut
7001 a Kabesch, Michael4 aut
7001 a Krokan, Hans E.4 aut
7001 a Elvestad, Maiken B.4 aut
7001 a Lissowska, Jolanta4 aut
7001 a Mates, Dana4 aut
7001 a Rudnai, Peter4 aut
7001 a Skorpen, Frank4 aut
7001 a Schreiber, Stefan4 aut
7001 a Soria, José M.4 aut
7001 a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva
7001 a Meneton, Pierre4 aut
7001 a Herçberg, Serge4 aut
7001 a Galan, Pilar4 aut
7001 a Szeszenia-Dabrowska, Neonilia4 aut
7001 a Zaridze, David4 aut
7001 a Génin, Emmanuel4 aut
7001 a Cardon, Lon R.4 aut
7001 a Lathrop, Mark4 aut
7102 a Uppsala universitetb Molekylär medicin4 org
7730 t European Journal of Human Geneticsd : Springer Science and Business Media LLCg 16:12, s. 1413-1429q 16:12<1413-1429x 1018-4813x 1476-5438
8564 u https://www.nature.com/articles/ejhg2008210.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103503
8564 8u https://doi.org/10.1038/ejhg.2008.210

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