Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

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Fältnamn	Indikatorer	Metadata
000		05078naa a2200829 4500
001		oai:DiVA.org:uu-185642
003		SwePub
008		121127s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1856422 URI
024	7	a https://doi.org/10.1371/journal.pone.00440082 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ramasamy, Adaikalavan4 aut
245	1 0	a Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA
264		c 2012-09-28
264	1	b Public Library of Science (PLoS),c 2012
338		a electronic2 rdacarrier
520		a Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies. Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations. Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P < 5x10(-8)) and three variants reported as suggestive (P < 5 x 10(-7)). We also searched for novel associations in APCAT (Stage 1) and followed-up the most promising variants in 4,035 asthmatics and 11,251 healthy controls (Stage 2). Finally, we conducted the first genome-wide screen for interactions with smoking or hay fever. Main Results: We observed association in the same direction for all thirteen previously reported variants and nominally replicated ten of them. One variant that was previously suggestive, rs11071559 in RORA, now reaches genome-wide significance when combined with our data (P = 2.4x10(-9)). We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (PStage1+Stage2 = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (PStage1+Stage2 = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. Finally, we found no strong evidence for gene-environment interactions with smoking or hay fever status. Conclusions: Population-based cohorts with simple asthma phenotypes represent a valuable and largely untapped resource for genetic studies of asthma.
700	1	a Kuokkanen, Mikko4 aut
700	1	a Vedantam, Sailaja4 aut
700	1	a Gajdos, Zofia K.4 aut
700	1	a Alves, Alexessander Couto4 aut
700	1	a Lyon, Helen N.4 aut
700	1	a Ferreira, Manuel A. R.4 aut
700	1	a Strachan, David P.4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Abramson, Michael J.4 aut
700	1	a Brown, Matthew A.4 aut
700	1	a Coin, Lachlan4 aut
700	1	a Dharmage, Shyamali C.4 aut
700	1	a Duffy, David L.4 aut
700	1	a Haahtela, Tari4 aut
700	1	a Heath, Andrew C.4 aut
700	1	a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn
700	1	a Kahonen, Mika4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Le Souef, Peter4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Madden, Pamela A. F.4 aut
700	1	a Marks, Guy B.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Matheson, Melanie C.4 aut
700	1	a Palmer, Cameron D.4 aut
700	1	a Palotie, Aarno4 aut
700	1	a Pouta, Anneli4 aut
700	1	a Robertson, Colin F.4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Widen, Elisabeth4 aut
700	1	a Wjst, Matthias4 aut
700	1	a Jarvis, Deborah L.4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a Thompson, Philip J.4 aut
700	1	a Wareham, Nick4 aut
700	1	a Eriksson, Johan4 aut
700	1	a Jousilahti, Pekka4 aut
700	1	a Laitinen, Tarja4 aut
700	1	a Pekkanen, Juha4 aut
700	1	a Raitakari, Olli T.4 aut
700	1	a O'Connor, George T.4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Hirschhorn, Joel N.4 aut
710	2	a Uppsala universitetb Lungmedicin och allergologi4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 7:9, s. e44008-q 7:9<e44008-x 1932-6203
856	4	u https://uu.diva-portal.org/smash/get/diva2:572335/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044008&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185642
856	4 8	u https://doi.org/10.1371/journal.pone.0044008

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Av författaren/redakt...: Ramasamy, Adaika ...; Kuokkanen, Mikko; Vedantam, Sailaj ...; Gajdos, Zofia K.; Alves, Alexessan ...; Lyon, Helen N.; visa fler...; Ferreira, Manuel ...; Strachan, David ...; Zhao, Jing Hua; Abramson, Michae ...; Brown, Matthew A ...; Coin, Lachlan; Dharmage, Shyama ...; Duffy, David L.; Haahtela, Tari; Heath, Andrew C.; Janson, Christer; Kahonen, Mika; Khaw, Kay-Tee; Laitinen, Jaana; Le Souef, Peter; Lehtimaki, Terho; Madden, Pamela A ...; Marks, Guy B.; Martin, Nicholas ...; Matheson, Melani ...; Palmer, Cameron ...; Palotie, Aarno; Pouta, Anneli; Robertson, Colin ...; Viikari, Jorma; Widen, Elisabeth; Wjst, Matthias; Jarvis, Deborah ...; Montgomery, Gran ...; Thompson, Philip ...; Wareham, Nick; Eriksson, Johan; Jousilahti, Pekk ...; Laitinen, Tarja; Pekkanen, Juha; Raitakari, Olli ...; O'Connor, George ...; Salomaa, Veikko; Jarvelin, Marjo- ...; Hirschhorn, Joel ...; visa färre...

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