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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04218naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-251515 | |
| 003 | SwePub | |
| 008 | 150420s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:130880383 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2515152 URI |
| 024 | 7 | a https://doi.org/10.2478/raon-2014-00152 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1308803832 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Carlsson, Jörgenu Uppsala universitet,Medicinsk strålningsvetenskap4 aut0 (Swepub:uu)jorgcarl |
| 245 | 1 0 | a EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides |
| 264 | c 2015-03-03 | |
| 264 | 1 | b Walter de Gruyter GmbH,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a Background. There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR or HER2 for therapy of metastasized urinary bladder canter and these methods are therefore not routinely used. Targeting radionuclides to the extracellular domain of the receptors is potentially a better possibility. Methods. EGFR- and HER2-expression was analyzed for primary tumors and corresponding metastases from 72 patients using immunohistochemistry and the internationally recommended HercepTest. Intracellular mutations were not analyzed since only the receptors were considered as targets and intracellular abnormalities should have minor effect on radiation dose. Results. EGFR was positive in 71% of the primary tumors and 69% of corresponding metastases. Local and distant metastases were EGFR-positive in 75% and 66% of the cases, respectively. The expression frequency of HER2 in related lesions was slightly higher (data from previous study). The EGFR-positive tumors expressed EGFR in metastases in 86% of the cases. The co-expression of EGFR and HER2 was 57% for tumors and 53% for metastases. Only 3% and 10% of the lesions were negative for both receptors in tumors and metastases, respectively. Thus, targeting these receptors with radionuclides might be applied for most patients. Conclusions. At least one of the EGFR- or HER2-receptors was present in most cases and co-expressed in more than half the cases. It is therefore interesting to deliver radionuclides for whole-body receptor-analysis, dosimetry and therapy. This can hopefully compensate for resistance to other therapies and more patients can hopefully be treated with curative instead of palliative intention. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a EGFR | |
| 653 | a HER2 | |
| 653 | a radionuclides | |
| 653 | a resistance | |
| 653 | a urinary bladder cancer metastases | |
| 700 | 1 | a Wester, Kennethu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)kennwest |
| 700 | 1 | a De La Torre, Manuelu Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)manutorr |
| 700 | 1 | a Malmström, Per-Unou Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)perunoms |
| 700 | 1 | a Gardmark, Trulsu Karolinska Institutet4 aut |
| 710 | 2 | a Uppsala universitetb Medicinsk strålningsvetenskap4 org |
| 773 | 0 | t Radiology and Oncologyd : Walter de Gruyter GmbHg 49:1, s. 50-58q 49:1<50-58x 1318-2099x 1581-3207 |
| 856 | 4 | u https://content.sciendo.com/downloadpdf/journals/raon/49/1/article-p50.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251515 |
| 856 | 4 8 | u https://doi.org/10.2478/raon-2014-0015 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130880383 |
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