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Sökning: onr:"swepub:oai:DiVA.org:uu-267194" > Associations of pro...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003824naa a2200397 4500
001oai:DiVA.org:uu-267194
003SwePub
008151119s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2671942 URI
0247 a https://doi.org/10.1038/srep156702 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Winham, Stacey J.u Mayo Clin, Hlth Sci Res, Rochester, MN USA.4 aut
2451 0a Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent
264 c 2015-10-27
264 1b Springer Science and Business Media LLC,c 2015
338 a electronic2 rdacarrier
520 a We previously demonstrated that prodynorphin (PDYN) haplotypes and single nucleotide polymorphism (SNP) rs2281285 are associated with alcohol dependence and the propensity to drink in negative emotional states, and recent studies suggest that PDYN gene effects on substance dependence risk may be sex-related. We examined sex-dependent associations of PDYN variation with alcohol dependence and related phenotypes, including negative craving, time until relapse after treatment and the length of sobriety episodes before seeking treatment, in discovery and validation cohorts of European ancestry. We found a significant haplotype-by-sex interaction (p = 0.03), suggesting association with alcohol dependence in males (p = 1E-4) but not females. The rs2281285G allele increased risk for alcohol dependence in males in the discovery cohort (OR = 1.49, p = 0.002), with a similar trend in the validation cohort (OR = 1.35, p = 0.086). However, rs2281285 showed a trend towards association with increased negative craving in females in both the discovery (beta = 10.16, p = 0.045) and validation samples (OR = 7.11, p = 0.066). In the discovery cohort, rs2281285 was associated with time until relapse after treatment in females (HR = 1.72, p = 0.037); in the validation cohort, it was associated with increased length of sobriety episodes before treatment in males (beta = 13.49, p = 0.001). Our findings suggest that sex-dependent effects of PDYN variants in alcohol dependence are phenotype-specific.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Preuss, Ulrich W.u Univ Halle Wittenberg, Dept Psychiat Psychotherapy & Psychosomat, D-06108 Halle, Germany.4 aut
7001 a Geske, Jennifer R.u Mayo Clin, Hlth Sci Res, Rochester, MN USA.4 aut
7001 a Zill, Peteru Ludwig Maximilians Univ Munchen, Dept Psychiat, Sect Psychiat Genet & Neurochem, Munich, Germany.4 aut
7001 a Heit, John A.u Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.4 aut
7001 a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200
7001 a Biernacka, Joanna M.u Mayo Clin, Hlth Sci Res, Rochester, MN USA.;Mayo Clin, Psychiat & Psychol, Rochester, MN 55902 USA.4 aut
7001 a Karpyak, Victor M.u Mayo Clin, Psychiat & Psychol, Rochester, MN 55902 USA.4 aut
7102 a Mayo Clin, Hlth Sci Res, Rochester, MN USA.b Univ Halle Wittenberg, Dept Psychiat Psychotherapy & Psychosomat, D-06108 Halle, Germany.4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 5q 5x 2045-2322
8564 u https://uu.diva-portal.org/smash/get/diva2:872560/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/srep15670.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267194
8564 8u https://doi.org/10.1038/srep15670

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