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Sökning: onr:"swepub:oai:DiVA.org:uu-318840" > Current Status of R...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03461naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-318840 | |
| 003 | SwePub | |
| 008 | 170330s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3188402 URI |
| 024 | 7 | a https://doi.org/10.3390/ph100100302 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Fani, Melpomeniu Division of Radiopharmaceutical Chemistry, University Hospital of Basel, 4031 Basel, Switzerland4 aut |
| 245 | 1 0 | a Current Status of Radiopharmaceuticals for the Theranostics of Neuroendocrine Neoplasms |
| 264 | c 2017-03-15 | |
| 264 | 1 | b MDPI AG,c 2017 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them. The Glucagon-Like Peptide-1 Receptor (GLP-1R) is highly expressed in benign insulinomas, the Cholecystokinin 2 (CCK2)/Gastrin receptor is expressed in different NENs, in particular medullary thyroid cancer, and the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor was found to be expressed in gastrointestinal and bronchial NENs, where interestingly, it is present in most of the sstr-negative and GLP-1R-negative NENs. Also in the field of sstr targeting new discoveries brought into light an alternative approach with the use of radiolabeled somatostatin receptor antagonists, instead of the clinically used agonists. The purpose of this review is to present the current status and the most innovative strategies for the diagnosis and treatment (theranostics) of neuroendocrine neoplasms using a cadre of radiolabeled regulatory peptides targeting their receptors. | |
| 653 | a CCK2 | |
| 653 | a GIP | |
| 653 | a GLP-1R | |
| 653 | a exendin-4 | |
| 653 | a gastrin | |
| 653 | a neuroendocrine neoplasms | |
| 653 | a radiolabeled peptides | |
| 653 | a somatostatin receptor antagonists | |
| 653 | a theranostics | |
| 700 | 1 | a Peitl, Petra Kolencu Department of Nuclear Medicine, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia4 aut |
| 700 | 1 | a Velikyan, Irina,d 1966-u Uppsala universitet,Radiologi,Preparativ läkemedelskemi4 aut0 (Swepub:uu)irinveli |
| 710 | 2 | a Division of Radiopharmaceutical Chemistry, University Hospital of Basel, 4031 Basel, Switzerlandb Department of Nuclear Medicine, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia4 org |
| 773 | 0 | t Pharmaceuticalsd : MDPI AGg 10:1q 10:1x 1424-8247 |
| 856 | 4 | u https://doi.org/10.3390/ph10010030y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1085898/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.mdpi.com/1424-8247/10/1/30/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318840 |
| 856 | 4 8 | u https://doi.org/10.3390/ph10010030 |
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