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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04289naa a2200757 4500 | |
| 001 | oai:DiVA.org:uu-343194 | |
| 003 | SwePub | |
| 008 | 180226s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3431942 URI |
| 024 | 7 | a https://doi.org/10.1111/jcpp.128432 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ruggeri, Barbara4 aut |
| 245 | 1 0 | a Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents |
| 264 | c 2017-12-02 | |
| 264 | 1 | b Wiley,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a OPRL1 methylation | |
| 653 | a adolescence | |
| 653 | a binge drinking | |
| 653 | a nucleus accumbens | |
| 653 | a stressful life events | |
| 700 | 1 | a Macare, Christine4 aut |
| 700 | 1 | a Stopponi, Serena4 aut |
| 700 | 1 | a Jia, Tianye4 aut |
| 700 | 1 | a Carvalho, Fabiana M4 aut |
| 700 | 1 | a Robert, Gabriel4 aut |
| 700 | 1 | a Banaschewski, Tobias4 aut |
| 700 | 1 | a Bokde, Arun L W4 aut |
| 700 | 1 | a Bromberg, Uli4 aut |
| 700 | 1 | a Büchel, Christian4 aut |
| 700 | 1 | a Cattrell, Anna4 aut |
| 700 | 1 | a Conrod, Patricia J4 aut |
| 700 | 1 | a Desrivières, Sylvane4 aut |
| 700 | 1 | a Flor, Herta4 aut |
| 700 | 1 | a Frouin, Vincent4 aut |
| 700 | 1 | a Gallinat, Jürgen4 aut |
| 700 | 1 | a Garavan, Hugh4 aut |
| 700 | 1 | a Gowland, Penny4 aut |
| 700 | 1 | a Heinz, Andreas4 aut |
| 700 | 1 | a Ittermann, Bernd4 aut |
| 700 | 1 | a Martinot, Jean Luc4 aut |
| 700 | 1 | a Martinot, Marie-Laure Paillère4 aut |
| 700 | 1 | a Nees, Frauke4 aut |
| 700 | 1 | a Papadopoulos-Orfanos, Dimitri4 aut |
| 700 | 1 | a Paus, Tomáš4 aut |
| 700 | 1 | a Poustka, Luise4 aut |
| 700 | 1 | a Smolka, Michael N4 aut |
| 700 | 1 | a Vetter, Nora C4 aut |
| 700 | 1 | a Walter, Henrik4 aut |
| 700 | 1 | a Whelan, Robert4 aut |
| 700 | 1 | a Sommer, Wolfgang H4 aut |
| 700 | 1 | a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200 |
| 700 | 1 | a Ciccocioppo, Roberto4 aut |
| 700 | 1 | a Schumann, Gunter4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
| 773 | 0 | t Journal of Child Psychology and Psychiatryd : Wileyg 9:6, s. 50-658q 9:6<50-658x 0021-9630x 1469-7610 |
| 856 | 4 | u http://www.tara.tcd.ie/bitstream/2262/82387/1/Ruggeri_et_al-2017-Journal_of_Child_Psychology_and_Psychiatry.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343194 |
| 856 | 4 8 | u https://doi.org/10.1111/jcpp.12843 |
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