Histopathological classification of non-functioning pituitary neuroendocrine tumors

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Fältnamn	Indikatorer	Metadata
000		04117naa a2200481 4500
001		oai:DiVA.org:uu-343603
003		SwePub
008		180228s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3436032 URI
024	7	a https://doi.org/10.1007/s11102-017-0855-12 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Manojlovic-Gacic, Emilijau Univ Belgrade, Inst Pathol, Sch Med, Belgrade, Serbia4 aut
245	1 0	a Histopathological classification of non-functioning pituitary neuroendocrine tumors
264		c 2017-12-23
264	1	b Springer Science and Business Media LLC,c 2018
338		a electronic2 rdacarrier
500		a Special Issue: SI
520		a Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogeneity, limited knowledge on their biology, and diverse methodological problems. We have searched PubMed database for data related to the histopathological classification of non-functioning pituitary tumors and methods for its application. Principles of the classification and grading presented in the recently released 4th edition of the World Health Organization classification of endocrine tumors have been summarized. Based on the expression of anterior pituitary hormones and pituitary specific transcription factors, gonadotroph tumors dominate within the group of clinically non-functioning tumors, followed by corticotroph type; however, other less common types of the non-functioning tumors can be identified. Assessment of tumor cell proliferation is important to identify "high-risk adenomas." A few subtypes of non-functioning tumors belong to the category of potentially aggressive tumors, independent of the cell proliferation rate. Here, we present up to date criteria for the classification of clinically non-functioning pituitary tumors, offer a diagnostic approach for the routine clinical use, and emphasize a need for inclusion of prognostic and predictive markers in the classification.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653		a Immunohistochemistry
653		a Non-functioning pituitary neuroendocrine tumor
653		a Pituitary adenoma
653		a Transcription factors
653		a Patologi
653		a Pathology
700	1	a Engström, Britt Edénu Uppsala universitet,Endokrinologi och mineralmetabolism4 aut0 (Swepub:uu)brittee
700	1	a Casar-Borota, Oliverau Uppsala universitet,Klinisk och experimentell patologi4 aut0 (Swepub:uu)olica753
710	2	a Univ Belgrade, Inst Pathol, Sch Med, Belgrade, Serbiab Endokrinologi och mineralmetabolism4 org
773	0	t Pituitaryd : Springer Science and Business Media LLCg 21:2, s. 119-129q 21:2<119-129x 1386-341Xx 1573-7403
856	4	u https://doi.org/10.1007/s11102-017-0855-1y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1186370/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://link.springer.com/content/pdf/10.1007%2Fs11102-017-0855-1.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343603
856	4 8	u https://doi.org/10.1007/s11102-017-0855-1

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