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Sökning: onr:"swepub:oai:DiVA.org:uu-371062" > Epigenetic influenc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006361naa a2200613 4500
001oai:DiVA.org:uu-371062
003SwePub
008181219s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:139653005
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3710622 URI
0247 a https://doi.org/10.1080/15592294.2018.15260282 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1396530052 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wang, Yunzhangu Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 aut
2451 0a Epigenetic influences on aging :b a longitudinal genome-wide methylation study in old Swedish twins
264 c 2018-10-13
264 1b Informa UK Limited,c 2018
338 a electronic2 rdacarrier
520 a Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3x10(-7)) using a longitudinal epigenome-wide association study design. We measured how estimated cellular compositions changed with age and how much they confounded the age effect. We validated the results in two independent longitudinal cohorts, where 118 CpGs were replicated in Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, 390 samples) (P<3.9x10(-5)), 594 in Lothian Birth Cohort (LBC, 3018 samples) (P<5.1x10(-5)) and 63 in both. Functional annotation of age-associated CpGs showed enrichment in CCCTC-binding factor (CTCF) and other transcription factor binding sites. We further investigated genetic influences on methylation and found no interaction between age and genetic effects in the 1316 age-associated CpGs. Moreover, in the same CpGs, methylation differences within twin pairs increased with 6.4% over 10 years, where monozygotic twins had smaller intra-pair differences than dizygotic twins. In conclusion, we show that age-related methylation changes persist in a longitudinal perspective, and are fairly stable across cohorts. The changes are under genetic influence, although this effect is independent of age. Moreover, methylation variability increase over time, especially in age-associated CpGs, indicating the increase of environmental contributions on DNA methylation with age.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a DNA methylation
653 a aging
653 a longitudinal study
653 a meQTL
653 a twin-pair analysis
7001 a Karlsson, Robertu Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 aut
7001 a Lampa, Erik,d 1977-u Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)erila302
7001 a Zhang, Qianu Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia4 aut
7001 a Hedman, Åsa Ku Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden4 aut0 (Swepub:uu)ashed124
7001 a Almgren, Malinu Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Stockholm, Sweden4 aut
7001 a Almqvist, Catarinau Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden4 aut
7001 a McRae, Allan F.u Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia4 aut
7001 a Marioni, Riccardo E.u Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland4 aut
7001 a Ingelsson, Erik,d 1975-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA4 aut0 (Swepub:uu)ering425
7001 a Visscher, Peter M.u Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia;Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia4 aut
7001 a Deary, Ian J.u Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland4 aut
7001 a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi,Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 aut0 (Swepub:uu)larslind
7001 a Morris, Tiffanyu UCL, Canc Inst, London, England4 aut
7001 a Beck, Stephanu UCL, Canc Inst, London, England4 aut
7001 a Pedersen, Nancy L.u Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 aut
7001 a Hagg, Sarau Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 aut
7102 a Karolinska Institutetb Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden4 org
7730 t Epigeneticsd : Informa UK Limitedg 13:9, s. 975-987q 13:9<975-987x 1559-2294x 1559-2308
8564 u https://doi.org/10.1080/15592294.2018.1526028y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1272684/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.tandfonline.com/doi/pdf/10.1080/15592294.2018.1526028?needAccess=true
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-371062
8564 8u https://doi.org/10.1080/15592294.2018.1526028
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139653005

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