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Tumour Growth Rate ...
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Lamarca, Angela
(författare)
Tumour Growth Rate as a validated early radiological biomarker able to reflect treatment-induced changes in Neuroendocrine Tumours : the GREPONET-2 study
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-392838
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392838URI
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https://doi.org/10.1158/1078-0432.CCR-19-0963DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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PURPOSE: TGR represents the percentage change in tumour volume per month (%/m). Previous results from the GREPONET study showed that TGR measured after 3 months (TGR3m) of starting systemic treatment (ST) or watch and wait (WW) was an early biomarker predicting progression-free survival (PFS) in NETs.EXPERIMENTAL DESIGN: Pts from7 centres with advanced grade(G) 1/2 NETs from the pancreas(P)/small bowel(SB) initiating ST/WW were eligible. Computed tomography (CT) / magnetic resonance imaging (MRI) performed at pre-baseline, baseline and 3(+/-1) months of study entry were retrospectively reviewed. Aim-1: explore treatment-induced changes in TGR (ΔTGR3m-BL) (paired T-test) and Aim-2: validate TGR3m (<0.8%/m vs ≥0.8%/m) as an early biomarker in an independent cohort (Kaplan-Meier/Cox Regression).RESULTS: Out of 785 pts screened, 127 were eligible. Mean (SD) TGR0 and TGR3m were 5.4%/m (14.9) and -1.4%/m (11.8), respectively. Mean(SD) ΔTGR3m-BL paired-difference was -6.8%/m(19.3) (p<0.001). Most marked ΔTGR3m-BL (mean (SD);p) were identified with targeted therapies (-11.3%/m(4.7);0.0237) and chemotherapy (-7.9%/m(3.4);0.0261). Multivariable analysis confirmed the absence of previous treatment (Odds Ratio (OR) 4.65 (95%CI 1.31-16.52); p-value0.018) and low TGR3m (continuous variable; OR 1.09 (95%CI 1.01-1.19); p-value0.042) to be independent predictors of radiological objective response. When the multivariable Cox Regression was adjusted to grade (p-value 0.004) and stage (p-value0.017), TGR3m≥0.8 (vs.<0.8) maintained its significance (p<0.001), while TGR0 and ΔTGR3m-BL did not. TGR3m was confirmed as an independent prognosis factor for PFS (external validation; Aim-2) (multivariable HR 2.21 (95%CI 1.21-3.70); p-value0.003).CONCLUSIONS: TGR has a role as biomarker for monitoring response to therapy for early prediction of PFS and radiological objective response.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ronot, Maxime
(författare)
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Moalla, Salma
(författare)
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Crona, JoakimUppsala universitet,Endokrin tumörbiologi(Swepub:uu)joacr310
(författare)
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Opalinska, Marta
(författare)
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Lopez Lopez, Carlos
(författare)
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Pezzutti, Daniela
(författare)
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Najran, Pavan
(författare)
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Carvalho, Luciana Franco do Prado de
(författare)
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Bezerra, Regis Otaviano Franca
(författare)
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Borg, Philip
(författare)
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Vietti Violi, Naik
(författare)
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Vidal Trueba, Hector
(författare)
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de Mestier, Louis
(författare)
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Schaefer, Niklaus
(författare)
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Baudin, Eric
(författare)
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Sundin, Anders,1954-Uppsala universitet,Radiologi(Swepub:uu)anderssu
(författare)
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Costa, Frederico P
(författare)
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Pavel, Marianne
(författare)
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Dromain, Clarisse
(författare)
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Uppsala universitetEndokrin tumörbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Cancer Research15:25, s. 6692-66991078-04321557-3265
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Lamarca, Angela
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Ronot, Maxime
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Moalla, Salma
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Crona, Joakim
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Opalinska, Marta
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Lopez Lopez, Car ...
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visa fler...
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Pezzutti, Daniel ...
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Najran, Pavan
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Carvalho, Lucian ...
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Bezerra, Regis O ...
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Borg, Philip
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Vietti Violi, Na ...
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Vidal Trueba, He ...
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de Mestier, Loui ...
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Schaefer, Niklau ...
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Baudin, Eric
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Sundin, Anders, ...
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Costa, Frederico ...
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Pavel, Marianne
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Dromain, Clariss ...
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