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FältnamnIndikatorerMetadata
00008568naa a2200697 4500
001oai:DiVA.org:uu-407324
003SwePub
008200325s2020 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:6bf267f4-4d5f-45b8-94f8-5dbcb9e788c9
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4073242 URI
0247 a https://doi.org/10.1055/s-0039-17008722 DOI
0247 a https://lup.lub.lu.se/record/6bf267f4-4d5f-45b8-94f8-5dbcb9e788c92 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bikdeli, Behnoodu Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Yale Univ, Yale Sch Med, Ctr Outcomes Res & Evaluat, New Haven, CT USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Yale University,Cardiovascular Research Foundation, New York,New York Presbyterian Hospital/Columbia University Medical Center4 aut
2451 0a Individual Patient Data Pooled Analysis of Randomized Trials of Bivalirudin versus Heparin in Acute Myocardial Infarction :b Rationale and Methodology
264 c 2019-12-09
264 1b Georg Thieme Verlag KG,c 2020
338 a print2 rdacarrier
520 a Background Individual randomized controlled trials (RCTs) of periprocedural anticoagulation with bivalirudin versus heparin during percutaneous coronary intervention (PCI) have reported conflicting results. Study-level meta-analyses lack granularity to adjust for confounders, explore heterogeneity, or identify subgroups that may particularly benefit or be harmed.Objective To overcome these limitations, we sought to develop an individual patient-data pooled database of RCTs comparing bivalirudin versus heparin.Methods We conducted a systematic review to identify RCTs in which ≥1,000 patients with acute myocardial infarction (AMI) undergoing PCI were randomized to bivalirudin versus heparin.Results From 738 identified studies, 8 RCTs met the prespecified criteria. The principal investigators of each study agreed to provide patient-level data. The data were pooled and checked for accuracy against trial publications, with discrepancies addressed by consulting with the trialists. Consensus-based definitions were created to resolve differing antithrombotic, procedural, and outcome definitions. The project required 3.5 years to complete, and the final database includes 27,409 patients (13,346 randomized to bivalirudin and 14,063 randomized to heparin).Conclusion We have created a large individual patient database of bivalirudin versus heparin RCTs in patients with AMI undergoing PCI. This endeavor may help identify the optimal periprocedural anticoagulation regimen for patient groups with different relative risks of adverse ischemic versus bleeding events, including those with ST-segment and non-ST-segment elevation MI, radial versus femoral access, use of a prolonged bivalirudin infusion or glycoprotein inhibitors, and others. Adherence to standardized techniques and rigorous validation processes should increase confidence in the accuracy and robustness of the results..
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a bivalirudin
653 a heparin
653 a pooled analysis
653 a percutaneous coronary intervention
653 a acute myocardial infarction
7001 a McAndrew, Thomasu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Crowley, Aaronu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Chen, Shmuelu Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York,New York Presbyterian Hospital/Columbia University Medical Center4 aut
7001 a Mehdipoor, Ghazalehu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Redfors, Bjornu Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden,New York Presbyterian Hospital/Columbia University Medical Center,Sahlgrenska University Hospital,Cardiovascular Research Foundation, New York4 aut
7001 a Liu, Yangbou Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Zhang, Zixuanu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Liu, Mengdanu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Zhang, Yiranu Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Francese, Dominic P.u Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York4 aut
7001 a Erlinge, Davidu Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups4 aut0 (Swepub:lu)kard-der
7001 a James, Stefan,d 1964-u Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Han, Yalingu Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China,Shenyang General Hospital of PLA4 aut
7001 a Li, Yiu Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China,Shenyang General Hospital of PLA4 aut
7001 a Kastrati, Adnanu Tech Univ, Deutsch Herzzentrum Munchen, Dept Cardiol, Munich, Germany,German Heart Centre, Munich,Technical University of Munich4 aut
7001 a Schuepke, Stefanieu Tech Univ, Deutsch Herzzentrum Munchen, Dept Cardiol, Munich, Germany,German Heart Centre, Munich,Technical University of Munich4 aut
7001 a Stables, Rod H.u Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England;Univ Liverpool, Liverpool, Merseyside, England,Liverpool Heart and Chest Hospital,University of Liverpool4 aut
7001 a Shahzad, Adeelu Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England,Liverpool Heart and Chest Hospital4 aut
7001 a Steg, Philippe Gabrielu Hop Bichat Claude Bernard, Paris, France;Royal Brompton Hosp, Imperial Coll, London, England,Hopital Bichat-Claude-Bernard AP-HP,Royal Brompton Hospital4 aut
7001 a Goldstein, Patricku Lille Univ Hosp, Lille, France,Lille University Hospital4 aut
7001 a Frigoli, Enricou Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland,Bern University Hospital,University of Bern4 aut
7001 a Mehran, Roxanau Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA,Icahn School of Medicine at Mount Sinai,Cardiovascular Research Foundation, New York4 aut
7001 a Valgimigli, Marcou Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland,University of Bern,Bern University Hospital4 aut
7001 a Stone, Gregg W.u Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA,Cardiovascular Research Foundation, New York,Icahn School of Medicine at Mount Sinai4 aut
7102 a Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Yale Univ, Yale Sch Med, Ctr Outcomes Res & Evaluat, New Haven, CT USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USAb Yale University4 org
7730 t Thrombosis and Haemostasisd : Georg Thieme Verlag KGg 120:2, s. 348-361q 120:2<348-361x 0340-6245x 2567-689X
8564 u https://europepmc.org/articles/pmc7040882?pdf=render
8564 u http://dx.doi.org/10.1055/s-0039-1700872y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407324
8564 8u https://doi.org/10.1055/s-0039-1700872
8564 8u https://lup.lub.lu.se/record/6bf267f4-4d5f-45b8-94f8-5dbcb9e788c9

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