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Sökning: onr:"swepub:oai:DiVA.org:uu-440710" > Effects of age, BMI...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007785naa a2200925 4500
001oai:DiVA.org:uu-440710
003SwePub
008210420s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:su-175038
009oai:prod.swepub.kib.ki.se:141752010
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4407102 URI
0247 a https://doi.org/10.1007/s00259-019-04403-72 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1750382 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1417520102 URI
040 a (SwePub)uud (SwePub)sud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tuisku, Jouniu Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland.4 aut
2451 0a Effects of age, BMI and sex on the glial cell marker TSPO :b a multicentre [11C]PBR28 HRRT PET study
264 c 2019-07-30
264 1b Springer,c 2019
338 a electronic2 rdacarrier
520 a Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [C-11]PBR28. Methods [C-11]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19-80 years; BMI range 17.6-36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (V-T) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts. Results There were significant positive correlations between age and V-T in the frontal and temporal cortex. BMI showed a significant negative correlation with V-T in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher V-T. A subgroup analysis revealed a positive correlation between V-T and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects. Conclusion These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a PET
653 a TSPO
653 a [C-11]PBR28
653 a Ageing
653 a Sex difference
653 a BMI
7001 a Plaven-Sigray, Pontusu Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.4 aut
7001 a Gaiser, Edward C.u Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.4 aut
7001 a Airas, Laurau Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Al-Abdulrasul, Haidaru Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Bruck, Annau Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Carson, Richard E.u Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.4 aut
7001 a Chen, Ming-Kaiu Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.4 aut
7001 a Cosgrove, Kelly P.u Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.4 aut
7001 a Ekblad, Laurau Univ Turku, Turku PET Ctr, Turku, Finland.4 aut
7001 a Esterlis, Irinau Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.4 aut
7001 a Farde, Larsu Karolinska Institutet4 aut
7001 a Forsberg, Antonu Karolinska Institutet4 aut
7001 a Halldin, Christeru Karolinska Institutet4 aut
7001 a Helin, Semiu Univ Turku, Turku PET Ctr, Turku, Finland.4 aut
7001 a Kosek, Evau Karolinska Institutet4 aut0 (Swepub:uu)evako353
7001 a Lekander, Matsu Stockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neuroscience, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden.4 aut0 (Swepub:su)mleka
7001 a Lindgren, Noorau Univ Turku, Turku PET Ctr, Turku, Finland.4 aut
7001 a Marjamaki, Paiviu Univ Turku, Turku PET Ctr, Turku, Finland.4 aut
7001 a Rissanen, Eerou Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Sucksdorff, Marcusu Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Varrone, Andreau Stockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden; Stockholm County, Sweden,Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden.4 aut
7001 a Collste, Karin4 aut
7001 a Gallezot, Jean-Dominique4 aut
7001 a Hillmer, Ansel4 aut
7001 a Huang, Yiyun4 aut
7001 a Hoglund, Caroline O.4 aut
7001 a Johansson, Jarkkou Karolinska Institutet4 aut
7001 a Jucaite, Aurelijau Karolinska Institutet4 aut
7001 a Lampa, Jon4 aut
7001 a Nabulsi, Nabeel4 aut
7001 a Pittman, Brian4 aut
7001 a Sandiego, Christine M.4 aut
7001 a Stenkrona, Peru Karolinska Institutet4 aut
7001 a Rinne, Juhau Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.4 aut
7001 a Matuskey, Davidu Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.4 aut
7001 a Cervenka, Simonu Karolinska Institutet4 aut0 (Swepub:uu)simce160
7102 a Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland.b Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.4 org
7730 t European Journal of Nuclear Medicine and Molecular Imagingd : Springerg 46:11, s. 2329-2338q 46:11<2329-2338x 1619-7070x 1619-7089
8564 u https://doi.org/10.1007/s00259-019-04403-7y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1545886/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s00259-019-04403-7.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440710
8564 8u https://doi.org/10.1007/s00259-019-04403-7
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-175038
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141752010

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