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Sökning: onr:"swepub:oai:gup.ub.gu.se/100031" > White matter hyperi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003666naa a2200661 4500
001oai:gup.ub.gu.se/100031
003SwePub
008240410s2005 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1945892
0247 a https://gup.ub.gu.se/publication/1000312 URI
0247 a https://doi.org/10.1002/gps.13422 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19458922 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Firbank, Michael J4 aut
2451 0a White matter hyperintensities and depression--preliminary results from the LADIS study.
264 1b Wiley,c 2005
520 a BACKGROUND: White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. METHODS: In a pan-European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three-point scale. RESULTS: We found depressive symptoms as assessed by the geriatric depression 15-item scale to be associated with WMH rating (Spearman's rho 0.11, p = 0.008) and also with the Euro-QOL health score (Spearman's rho -0.5, p < 0.001). In a ordinal logistic regression model, QOL was found to strongly predict GDS score (p < 0.001) and severe vs mild WMH were associated with increased depression (p = 0.028). The relationship between history of severe depression and WMH score was examined, but there were no differences either between those with and without a history of severe depression, or those with an early vs late onset of depression. CONCLUSIONS: The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor.
653 a Aged
653 a Aged
653 a 80 and over
653 a Brain
653 a pathology
653 a Depression
653 a pathology
653 a Depressive Disorder
653 a pathology
653 a Female
653 a Geriatric Assessment
653 a Humans
653 a Hypertension
653 a pathology
653 a psychology
653 a Magnetic Resonance Imaging
653 a methods
653 a Male
653 a Psychiatric Status Rating Scales
653 a Quality of Life
653 a Stroke
653 a pathology
653 a psychology
7001 a O'Brien, John T4 aut
7001 a Pakrasi, Sanjeet4 aut
7001 a Pantoni, Leonardo4 aut
7001 a Simoni, Michela4 aut
7001 a Erkinjuntti, Timo4 aut
7001 a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience4 aut0 (Swepub:gu)xwaand
7001 a Wahlund, Lars-Olofu Karolinska Institutet4 aut
7001 a van Straaten, Ilse4 aut
7001 a Inzitari, Domenico4 aut
7102 a Göteborgs universitetb Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap4 org
7730 t International journal of geriatric psychiatryd : Wileyg 20:7, s. 674-9q 20:7<674-9x 0885-6230x 1099-1166
8564 8u https://gup.ub.gu.se/publication/100031
8564 8u https://doi.org/10.1002/gps.1342
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1945892

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