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Sökning: onr:"swepub:oai:gup.ub.gu.se/165228" > P2RX7: Expression R...

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FältnamnIndikatorerMetadata
00005752naa a2200853 4500
001oai:gup.ub.gu.se/165228
003SwePub
008240910s2012 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e76fdfc7-a9a1-4a08-b5e0-1ac576919a5c
009oai:prod.swepub.kib.ki.se:125350930
009oai:prod.swepub.kib.ki.se:124980962
0247 a https://gup.ub.gu.se/publication/1652282 URI
0247 a https://doi.org/10.1371/journal.pone.00430572 DOI
0247 a https://lup.lub.lu.se/record/31914482 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1253509302 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1249809622 URI
040 a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Backlund, L.u Karolinska Institutet4 aut
2451 0a P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1
264 c 2012-08-28
264 1b Public Library of Science (PLoS),c 2012
520 a Context: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. Objectives: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is associated with rapid cycling in bipolar patients. Design: Gene expression analysis in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and case-case and case-control SNP/haplotype association analyses in patients. Participants: Healthy volunteers at the sleep research center, University of California, Irvine Medical Center (UCIMC), USA (n = 8) and Swedish outpatients recruited from specialized psychiatric clinics for bipolar disorder, diagnosed with bipolar disorder type 1 (n = 569; rapid cycling: n = 121) and anonymous blood donor controls (n = 1,044). Results: P2RX7 RNA levels were significantly increased during sleep deprivation in PBMCs from healthy volunteers (p = 2.3*10(-9)). The P2RX7 rs2230912_A allele was more common (OR = 2.2, p = 0.002) and the ACGTTT haplotype in P2RX7 (rs1718119 to rs1621388) containing the protective rs2230912_G allele (OR = 0.45-0.49, p = 0.003-0.005) was less common, among rapid cycling cases compared to non-rapid cycling bipolar patients and blood donor controls. Conclusions: Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder. This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a single-nucleotide polymorphisms
653 a neurotrophic factor bdnf
653 a linkage
653 a disequilibrium
653 a synthase kinase-3
653 a p2x(7) receptors
653 a circadian clock
653 a mood disorders
653 a protein-kinase
653 a phase-shifts
653 a gene
653 a netics
653 a v150b
653 a p1063
653 a netics
653 a v153b
653 a p847
653 a netics
653 a v150b
653 a p295
653 a netics
653 a v141b
653 a p374
7001 a Lavebratt, C.u Karolinska Institutet4 aut
7001 a Frisen, L.u Karolinska Institutet4 aut
7001 a Nikamo, P.u Karolinska Institutet4 aut
7001 a Sudic, D. H.4 aut
7001 a Träskman Bendz, Lilu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)psyk-lt8
7001 a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt
7001 a Edman, G.u Karolinska Institutet4 aut
7001 a Vawter, M. P.4 aut
7001 a Osby, U.u Karolinska Institutet4 aut
7001 a Schalling, M.u Karolinska Institutet4 aut
7102 a Karolinska Institutetb Psykiatri, Lund4 org
7730 t Plos Oned : Public Library of Science (PLoS)g 27q 7:8x 1932-6203
7730 t EUROPEAN PSYCHIATRYd : Public Library of Science (PLoS)g 27q 27x 0924-9338
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043057&type=printable
8564 u https://portal.research.lu.se/files/3526402/3736823.pdfx primaryx freey FULLTEXT
8564 u http://dx.doi.org/10.1371/journal.pone.0043057x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/165228
8564 8u https://doi.org/10.1371/journal.pone.0043057
8564 8u https://lup.lub.lu.se/record/3191448
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125350930
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124980962

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