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Sökning: onr:"swepub:oai:gup.ub.gu.se/165228" > P2RX7: Expression R...

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FältnamnIndikatorerMetadata
00005752naa a2200853 4500
001oai:gup.ub.gu.se/165228
003SwePub
008240910s2012 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e76fdfc7-a9a1-4a08-b5e0-1ac576919a5c
009oai:prod.swepub.kib.ki.se:125350930
009oai:prod.swepub.kib.ki.se:124980962
024a https://gup.ub.gu.se/publication/1652282 URI
024a https://doi.org/10.1371/journal.pone.00430572 DOI
024a https://lup.lub.lu.se/record/31914482 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1253509302 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1249809622 URI
040 a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Backlund, L.u Karolinska Institutet4 aut
2451 0a P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1
264 c 2012-08-28
264 1b Public Library of Science (PLoS),c 2012
520 a Context: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. Objectives: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is associated with rapid cycling in bipolar patients. Design: Gene expression analysis in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and case-case and case-control SNP/haplotype association analyses in patients. Participants: Healthy volunteers at the sleep research center, University of California, Irvine Medical Center (UCIMC), USA (n = 8) and Swedish outpatients recruited from specialized psychiatric clinics for bipolar disorder, diagnosed with bipolar disorder type 1 (n = 569; rapid cycling: n = 121) and anonymous blood donor controls (n = 1,044). Results: P2RX7 RNA levels were significantly increased during sleep deprivation in PBMCs from healthy volunteers (p = 2.3*10(-9)). The P2RX7 rs2230912_A allele was more common (OR = 2.2, p = 0.002) and the ACGTTT haplotype in P2RX7 (rs1718119 to rs1621388) containing the protective rs2230912_G allele (OR = 0.45-0.49, p = 0.003-0.005) was less common, among rapid cycling cases compared to non-rapid cycling bipolar patients and blood donor controls. Conclusions: Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder. This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a single-nucleotide polymorphisms
653 a neurotrophic factor bdnf
653 a linkage
653 a disequilibrium
653 a synthase kinase-3
653 a p2x(7) receptors
653 a circadian clock
653 a mood disorders
653 a protein-kinase
653 a phase-shifts
653 a gene
653 a netics
653 a v150b
653 a p1063
653 a netics
653 a v153b
653 a p847
653 a netics
653 a v150b
653 a p295
653 a netics
653 a v141b
653 a p374
700a Lavebratt, C.u Karolinska Institutet4 aut
700a Frisen, L.u Karolinska Institutet4 aut
700a Nikamo, P.u Karolinska Institutet4 aut
700a Sudic, D. H.4 aut
700a Träskman Bendz, Lilu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)psyk-lt8
700a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt
700a Edman, G.u Karolinska Institutet4 aut
700a Vawter, M. P.4 aut
700a Osby, U.u Karolinska Institutet4 aut
700a Schalling, M.u Karolinska Institutet4 aut
710a Karolinska Institutetb Psykiatri, Lund4 org
773t Plos Oned : Public Library of Science (PLoS)g 27q 7:8x 1932-6203
773t EUROPEAN PSYCHIATRYd : Public Library of Science (PLoS)g 27q 27x 0924-9338
856u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043057&type=printable
856u https://portal.research.lu.se/files/3526402/3736823.pdfx primaryx freey FULLTEXT
856u http://dx.doi.org/10.1371/journal.pone.0043057x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/165228
8564 8u https://doi.org/10.1371/journal.pone.0043057
8564 8u https://lup.lub.lu.se/record/3191448
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125350930
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124980962

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