Sökning: onr:"swepub:oai:gup.ub.gu.se/176192" > An international mu...
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000 | 04440naa a2200637 4500 | |
001 | oai:gup.ub.gu.se/176192 | |
003 | SwePub | |
008 | 240910s2013 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:914651b9-e3d4-4ffc-a6a7-e57d16311222 | |
024 | 7 | a https://gup.ub.gu.se/publication/1761922 URI |
024 | 7 | a https://doi.org/10.1111/cod.120362 DOI |
024 | 7 | a https://lup.lub.lu.se/record/36279632 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bråred Christensson, Johanna,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Department of Chemistry and Molecular Biology,Institute of Clinical Sciences, Department of Dermatology and Venereology4 aut0 (Swepub:gu)xbrarj |
245 | 1 0 | a An international multicentre study on the allergenic activity of air-oxidized R-limonene |
264 | c 2013-03-20 | |
264 | 1 | b Wiley,c 2013 |
520 | a Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2–3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3–12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0–24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a allergic contact dermatitis | |
653 | a autoxidation | |
653 | a CAS 5989-27-5 | |
653 | a dose per unit area | |
653 | a fragrance allergy | |
653 | a potent contact allergens | |
653 | a dermatitis patients | |
653 | a skin sensitization | |
653 | a oxidation-products | |
653 | a fragrance terpenes | |
653 | a citrus solvent | |
653 | a linalool | |
653 | a hydroperoxide | |
653 | a autoxidation | |
653 | a exposure | |
700 | 1 | a Andersen, K. E.4 aut |
700 | 1 | a Bruze, Magnusu Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups4 aut0 (Swepub:lu)derm-mbr |
700 | 1 | a Johansen, J. D.4 aut |
700 | 1 | a Garcia-Bravo, B.4 aut |
700 | 1 | a Gimenez-Arnau, A.4 aut |
700 | 1 | a Goh, C. L.4 aut |
700 | 1 | a Nixon, R.4 aut |
700 | 1 | a White, I. R.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
773 | 0 | t Contact Dermatitisd : Wileyg 68:4, s. 214-223q 68:4<214-223x 0105-1873 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/23510342?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1111/cod.12036y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/176192 |
856 | 4 8 | u https://doi.org/10.1111/cod.12036 |
856 | 4 8 | u https://lup.lub.lu.se/record/3627963 |
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