Sökning: onr:"swepub:oai:gup.ub.gu.se/196064" > Impact of type 2 di...
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000 | 06187naa a2201141 4500 | |
001 | oai:gup.ub.gu.se/196064 | |
003 | SwePub | |
008 | 240910s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129091865 | |
009 | oai:DiVA.org:uu-228006 | |
024 | 7 | a https://gup.ub.gu.se/publication/1960642 URI |
024 | 7 | a https://doi.org/10.2337/db13-09492 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1290918652 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2280062 URI |
040 | a (SwePub)gud (SwePub)kid (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dimas, Antigone S4 aut |
245 | 1 0 | a Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. |
264 | c 2014-05-15 | |
264 | 1 | b American Diabetes Association,c 2014 |
500 | a De fem sista författarna delar sistaförfattarskapet. | |
520 | a Patients with established type 2 diabetes display both beta-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci and indices of proinsulin processing, insulin secretion and insulin sensitivity. We included data from up to 58,614 non-diabetic subjects with basal measures, and 17,327 with dynamic measures. We employed additive genetic models with adjustment for sex, age and BMI, followed by fixed-effects inverse variance meta-analyses. Cluster analyses grouped risk loci into five major categories based on their relationship to these continuous glycemic phenotypes. The first cluster (PPARG, KLF14, IRS1, GCKR) was characterized by primary effects on insulin sensitivity. The second (MTNR1B, GCK) featured risk alleles associated with reduced insulin secretion and fasting hyperglycemia. ARAP1 constituted a third cluster characterized by defects in insulin processing. A fourth cluster (including TCF7L2, SLC30A8, HHEX/IDE, CDKAL1, CDKN2A/2B) was defined by loci influencing insulin processing and secretion without detectable change in fasting glucose. The final group contained twenty risk loci with no clear-cut associations to continuous glycemic traits. By assembling extensive data on continuous glycemic traits, we have exposed the diverse mechanisms whereby type 2 diabetes risk variants impact disease predisposition. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Lagou, Vasiliki4 aut |
700 | 1 | a Barker, Adam4 aut |
700 | 1 | a Knowles, Joshua W4 aut |
700 | 1 | a Mägi, Reedik4 aut |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Benazzo, Andrea4 aut |
700 | 1 | a Rybin, Denis4 aut |
700 | 1 | a Jackson, Anne U4 aut |
700 | 1 | a Stringham, Heather M4 aut |
700 | 1 | a Song, Ciu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:uu)ciaso492 |
700 | 1 | a Fischer-Rosinsky, Antje4 aut |
700 | 1 | a Boesgaard, Trine Welløv4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Abbasi, Fahim A4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Hao, Ke4 aut |
700 | 1 | a Yang, Xia4 aut |
700 | 1 | a Lecoeur, Cécile4 aut |
700 | 1 | a Barroso, Inês4 aut |
700 | 1 | a Bonnycastle, Lori L4 aut |
700 | 1 | a Böttcher, Yvonne4 aut |
700 | 1 | a Bumpstead, Suzannah4 aut |
700 | 1 | a Chines, Peter S4 aut |
700 | 1 | a Erdos, Michael R4 aut |
700 | 1 | a Graessler, Jurgen4 aut |
700 | 1 | a Kovacs, Peter4 aut |
700 | 1 | a Morken, Mario A4 aut |
700 | 1 | a Narisu, Narisu4 aut |
700 | 1 | a Payne, Felicity4 aut |
700 | 1 | a Stancakova, Alena4 aut |
700 | 1 | a Swift, Amy J4 aut |
700 | 1 | a Tönjes, Anke4 aut |
700 | 1 | a Bornstein, Stefan R4 aut |
700 | 1 | a Cauchi, Stéphane4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Meyre, David4 aut |
700 | 1 | a Schwarz, Peter E H4 aut |
700 | 1 | a Häring, Hans-Ulrich4 aut |
700 | 1 | a Smith, Ulf,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsmiul |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Bergman, Richard N4 aut |
700 | 1 | a Collins, Francis S4 aut |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Quertemous, Thomas4 aut |
700 | 1 | a Lind, Lars4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Pfeiffer, Andreas F H4 aut |
700 | 1 | a Spranger, Joachim4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Meigs, James B4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Dupuis, Josée4 aut |
700 | 1 | a Watanabe, Richard M4 aut |
700 | 1 | a Florez, Jose C4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a MAGIC Investigators,4 aut |
710 | 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 63:6, s. 2158-2171q 63:6<2158-2171x 1939-327Xx 0012-1797 |
856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/63/6/2158.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/196064 |
856 | 4 8 | u https://doi.org/10.2337/db13-0949 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129091865 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228006 |
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