Sökning: onr:"swepub:oai:gup.ub.gu.se/265789" > Evolution of cerebr...
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000 | 03391naa a2200361 4500 | |
001 | oai:gup.ub.gu.se/265789 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2657892 URI |
024 | 7 | a https://doi.org/10.1016/j.parkreldis.2018.01.0182 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Førland, Marthe Gurine4 aut |
245 | 1 0 | a Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease. |
264 | 1 | b Elsevier BV,c 2018 |
520 | a Cerebrospinal fluid (CSF) total α-synuclein is considered a potential biomarker for Parkinson's disease (PD), but little is known about the evolution of this marker during the course of the disease. Our objective was to investigate whether CSF total α-synuclein concentrations change over time and are associated with motor and cognitive function in PD.CSF total α-synuclein concentrations were quantified in 56 longitudinally followed PD patients, 27 of whom provided CSF repeatedly 2 and/or 4 years later. Another 18 subjects were included as controls. The samples were analyzed using two independent, validated ELISA methods: our recently developed and validated in-house ELISA and a commercial kit from BioLegend.CSF total α-synuclein levels did not distinguish PD patients from controls, displayed no substantial changes during a period of up to 4 years, and did not predict subsequent motor or cognitive decline. These findings were consistent for both analytical methods.Our findings do not support the clinical utility of total α-synuclein as a single diagnostic or prognostic biomarker in PD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Öhrfelt, Annika,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xohrfa |
700 | 1 | a Tysnes, Ole-Bjørn4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Pedersen, Kenn Freddy4 aut |
700 | 1 | a Alves, Guido4 aut |
700 | 1 | a Lange, Johannes4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Parkinsonism & related disordersd : Elsevier BVg 49, s. 4-8q 49<4-8x 1873-5126x 1353-8020 |
856 | 4 | u https://discovery.ucl.ac.uk/10057936/1/Zetterberg_Forland.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/265789 |
856 | 4 8 | u https://doi.org/10.1016/j.parkreldis.2018.01.018 |
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