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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05242naa a2200841 4500 | |
| 001 | oai:gup.ub.gu.se/268617 | |
| 003 | SwePub | |
| 008 | 240410s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2686172 URI |
| 024 | 7 | a https://doi.org/10.1530/ec-18-00472 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xjgudn |
| 245 | 1 0 | a Growth Hormone Research Society perspective on biomarkers of GH action in children and adults |
| 264 | 1 | b Bioscientifica,c 2018 |
| 520 | a Objective: The Growth Hormone Research Society (GRS) convened a Workshop in 2017 to evaluate clinical endpoints, surrogate endpoints and biomarkers during GH treatment of children and adults and in patients with acromegaly. Participants: GRS invited 34 international experts including clinicians, basic scientists, a regulatory scientist and physicians from the pharmaceutical industry. Evidence: Current literature was reviewed and expert opinion was utilized to establish the state of the art and identify current gaps and unmet needs. Consensus process: Following plenary presentations, breakout groups discussed questions framed by the planning committee. The attendees re-convened after each breakout session to share the group reports. A writing team compiled the breakout session reports into a document that was subsequently discussed and revised by participants. This was edited further and circulated for final review after the meeting. Participants from pharmaceutical companies were not part of the writing process. Conclusions: The clinical endpoint in paediatric GH treatment is adult height with height velocity as a surrogate endpoint. Increased life expectancy is the ideal but unfeasible clinical endpoint of GH treatment in adult GH-deficient patients (GHDA) and in patients with acromegaly. The pragmatic clinical endpoints in GHDA include normalization of body composition and quality of life, whereas symptom relief and reversal of comorbidities are used in acromegaly. Serum IGF-I is widely used as a biomarker, even though it correlates weakly with clinical endpoints in GH treatment, whereas in acromegaly, normalization of IGF-I may be related to improvement in mortality. There is an unmet need for novel biomarkers that capture the pleiotropic actions of GH in relation to GH treatment and in patients with acromegaly. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a GH | |
| 653 | a IGF-I | |
| 653 | a GH deficiency | |
| 653 | a acromegaly | |
| 653 | a surrogate end-points | |
| 653 | a idiopathic short stature | |
| 653 | a replacement therapy | |
| 653 | a igf-i | |
| 653 | a consensus statement | |
| 653 | a deficient patients | |
| 653 | a disease-activity | |
| 653 | a turner | |
| 653 | a syndrome | |
| 653 | a serum | |
| 653 | a pegvisomant | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Bidlingmaier, M.4 aut |
| 700 | 1 | a Biller, B. M. K.4 aut |
| 700 | 1 | a Boguszewski, M.4 aut |
| 700 | 1 | a Casanueva, F. F.4 aut |
| 700 | 1 | a Chanson, P.4 aut |
| 700 | 1 | a Clayton, P. E.4 aut |
| 700 | 1 | a Choong, C. S.4 aut |
| 700 | 1 | a Clemmons, D.4 aut |
| 700 | 1 | a Dattani, M.4 aut |
| 700 | 1 | a Frystyk, J.4 aut |
| 700 | 1 | a Ho, K.4 aut |
| 700 | 1 | a Hoffman, A. R.4 aut |
| 700 | 1 | a Horikawa, R.4 aut |
| 700 | 1 | a Juul, A.4 aut |
| 700 | 1 | a Kopchick, J. J.4 aut |
| 700 | 1 | a Luo, X. P.4 aut |
| 700 | 1 | a Neggers, S.4 aut |
| 700 | 1 | a Netchine, I.4 aut |
| 700 | 1 | a Olsson, Daniel S,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xolssd |
| 700 | 1 | a Radovick, S.4 aut |
| 700 | 1 | a Rosenfeld, R.4 aut |
| 700 | 1 | a Ross, R. J.4 aut |
| 700 | 1 | a Schilbach, K.4 aut |
| 700 | 1 | a Solberg, P.4 aut |
| 700 | 1 | a Strasburger, C.4 aut |
| 700 | 1 | a Trainer, P.4 aut |
| 700 | 1 | a Yuen, K. C. J.4 aut |
| 700 | 1 | a Wickstrom, K.4 aut |
| 700 | 1 | a Jorgensen, J. O. L.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
| 773 | 0 | t Endocrine Connectionsd : Bioscientificag 7:3, s. R126-R134q 7:3<R126-R134x 2049-3614 |
| 856 | 4 | u https://ec.bioscientifica.com/downloadpdf/journals/ec/7/3/EC-18-0047.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/268617 |
| 856 | 4 8 | u https://doi.org/10.1530/ec-18-0047 |
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