Sökning: onr:"swepub:oai:gup.ub.gu.se/303351" > Replication study o...
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000 | 07171naa a2201045 4500 | |
001 | oai:gup.ub.gu.se/303351 | |
003 | SwePub | |
008 | 240910s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-90976 | |
009 | oai:prod.swepub.kib.ki.se:146304983 | |
024 | 7 | a https://gup.ub.gu.se/publication/3033512 URI |
024 | 7 | a https://doi.org/10.1002/alz.123222 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-909762 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1463049832 URI |
040 | a (SwePub)gud (SwePub)orud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shi, Liuu Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
245 | 1 0 | a Replication study of plasma proteins relating to Alzheimer's pathology. |
264 | c 2021-03-31 | |
264 | 1 | b Wiley,c 2021 |
500 | a Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF grant from the European Union's Seventh Framework Programme (FP7/2007-2013) 115372European Commission Joint Research Centre QLRT-2001-2455 37670Stichting voor Alzheimer Onderzoek 11020 13007 15005Department of Health of the Basque Government 17.0.1.08.12.0000.2.454.01.41142.001.HUniversity of Antwerp Research Fund European Research Council (ERC) European Commission 681712Swedish State Support for Clinical Research ALFGBG720931Alzheimer Drug Discovery Foundation (ADDF), USA 201809-2016862UK Dementia Research Institute at UCL NIHR biomedical research center at UCLH EFPIA companies' | |
520 | a This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a ATN framework | |
700 | 1 | a Winchester, Laura M4 aut |
700 | 1 | a Westwood, Sarah4 aut |
700 | 1 | a Baird, Alison L4 aut |
700 | 1 | a Anand, Sneha N4 aut |
700 | 1 | a Buckley, Noel J4 aut |
700 | 1 | a Hye, Abdul4 aut |
700 | 1 | a Ashton, Nicholas J4 aut |
700 | 1 | a Bos, Isabelle4 aut |
700 | 1 | a Vos, Stephanie J B4 aut |
700 | 1 | a Kate, Mara Ten4 aut |
700 | 1 | a Scheltens, Philip4 aut |
700 | 1 | a Teunissen, Charlotte E4 aut |
700 | 1 | a Vandenberghe, Rik4 aut |
700 | 1 | a Gabel, Silvy4 aut |
700 | 1 | a Meersmans, Karen4 aut |
700 | 1 | a Engelborghs, Sebastiaan4 aut |
700 | 1 | a De Roeck, Ellen E4 aut |
700 | 1 | a Sleegers, Kristel4 aut |
700 | 1 | a Frisoni, Giovanni B4 aut |
700 | 1 | a Blin, Olivier4 aut |
700 | 1 | a Richardson, Jill C4 aut |
700 | 1 | a Bordet, Régis4 aut |
700 | 1 | a Molinuevo, José L4 aut |
700 | 1 | a Rami, Lorena4 aut |
700 | 1 | a Wallin, Anders4 aut |
700 | 1 | a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xketpe |
700 | 1 | a Tsolaki, Magda4 aut |
700 | 1 | a Verhey, Frans4 aut |
700 | 1 | a Lléo, Alberto4 aut |
700 | 1 | a Sala, Isabel4 aut |
700 | 1 | a Popp, Julius4 aut |
700 | 1 | a Peyratout, Gwendoline4 aut |
700 | 1 | a Martinez-Lage, Pablo4 aut |
700 | 1 | a Tainta, Mikel4 aut |
700 | 1 | a Johannsen, Peter4 aut |
700 | 1 | a Freund-Levi, Yvonne,d 1956-u Örebro universitet,Institutionen för medicinska vetenskaper,Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, Stockholm, Sweden; Department of Neurobiology, Caring Sciences and Society (NVS), Stockholm, Sweden4 aut0 (Swepub:oru)yfi |
700 | 1 | a Frölich, Lutz4 aut |
700 | 1 | a Dobricic, Valerija4 aut |
700 | 1 | a Legido-Quigley, Cristina4 aut |
700 | 1 | a Barkhof, Frederik4 aut |
700 | 1 | a Andreasson, Ulf4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Streffer, Johannes4 aut |
700 | 1 | a Lill, Christina M4 aut |
700 | 1 | a Bertram, Lars4 aut |
700 | 1 | a Visser, Pieter Jelle4 aut |
700 | 1 | a Kolb, Hartmuth C4 aut |
700 | 1 | a Narayan, Vaibhav A4 aut |
700 | 1 | a Lovestone, Simon4 aut |
700 | 1 | a Nevado-Holgado, Alejo Ju Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
710 | 2 | a Department of Psychiatry, University of Oxford, Oxford, UKb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & dementia : the journal of the Alzheimer's Associationd : Wileyg 17:9, s. 1452-1464q 17:9<1452-1464x 1552-5279x 1552-5260 |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 17:9, s. 1452-1464q 17:9<1452-1464x 1552-5260 |
856 | 4 8 | u https://gup.ub.gu.se/publication/303351 |
856 | 4 8 | u https://doi.org/10.1002/alz.12322 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90976 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146304983 |
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