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Sökning: onr:"swepub:oai:gup.ub.gu.se/89260" > Development of a ne...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004640naa a2200613 4500
001oai:gup.ub.gu.se/89260
003SwePub
008240410s2006 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1938842
0247 a https://gup.ub.gu.se/publication/892602 URI
0247 a https://doi.org/10.1159/0000953812 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19388422 URI
040 a (SwePub)gud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Madureira, Sofia4 aut
2451 0a Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly study (LADIS): Experience and baseline data
264 c 2006-09-15
264 1b S. Karger AG,c 2006
520 a The relationship between age-related white matter changes and cognitive performance in independent elderly people is still not clear. The Leukoaraiosis and Disability in the Elderly study (LADIS) involves 11 European centers. It aims to assess the role of the age-related white matter changes as an independent factor in the transition to disability, and in cognitive performance of an independent elderly population. A comprehensive neuropsychological battery was constructed in order to harmonize the cognitive assessment across countries. Patients were evaluated at baseline and during the 3-year follow-up with the Mini-Mental State Examination, a modified version of the VADAS-Cog (Alzheimer’s Dementia Assessment Scale plus tests of Delayed recall, Symbol digit, Digit span, Maze, Digit cancellation and Verbal fluency), Trail making and Stroop test. Six hundred thirty-eight patients (mean age 74 ± 5 years; mean educational level 10 ± 4, F/M: 351/287) were included in this study. Neuropsychological data were analyzed test by test and also grouped in three compound measures (executive, memory and speed/motor control domains). Older subjects (>74 years) performed significantly worse than younger subjects on the ADAS-Mod and on the tests of memory (t<sub>631</sub> = 3.25; p = 0.001), executive functions (t<sub>581</sub> = 4.68; p = 0.001) and speed/motor control (t<sub>587</sub> = 4.01; p = 0.001). Participants with higher educational level (>8 years of school) showed better performances on the compound measures for memory (t<sub>631</sub> = 3.25; p = 0.001), executive functions (t<sub>581</sub> = 4.68; p = 0.001) and speed/motor control (t<sub>587</sub> = 4.01; p = 0.001). Using multiple regression analysis models to study the influence of demographic variables on cognitive performance, age and education remained important variables influencing test performance. In the LADIS population baseline data, older age and lower educational levels negatively influence neuropsychological performance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a white-matter lesions
653 a disease assessment scale
653 a alzheimers-disease
653 a dementia
653 a rotterdam
653 a education
653 a cognition
653 a people
7001 a Verdelho, Ana4 aut
7001 a Ferro, José M.4 aut
7001 a Basile, Anna-Maria4 aut
7001 a Chabriat, Hugues4 aut
7001 a Erkinjuntti, Timo4 aut
7001 a Fazekas, Franz4 aut
7001 a Hennerici, Michael4 aut
7001 a O'Brien, John4 aut
7001 a Pantoni, Leonardo4 aut
7001 a Salvadori, Emilia4 aut
7001 a Scheltens, Philip4 aut
7001 a Visser, Marieke C.4 aut
7001 a Wahlund, Lars-Olofu Karolinska Institutet4 aut
7001 a Waldemar, Gunhild4 aut
7001 a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand
7001 a Inzitari, Domenico4 aut
7102 a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t NEUROEPIDEMIOLOGYd : S. Karger AGg 27:2, s. 101-116q 27:2<101-116x 0251-5350x 1423-0208
8564 u https://www.karger.com/Article/Pdf/95381
8564 8u https://gup.ub.gu.se/publication/89260
8564 8u https://doi.org/10.1159/000095381
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938842

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