Search: onr:"swepub:oai:gup.ub.gu.se/89349" > IL6 gene promoter p...
Fältnamn | Indikatorer | Metadata |
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000 | 05770naa a2201009 4500 | |
001 | oai:gup.ub.gu.se/89349 | |
003 | SwePub | |
008 | 240910s2006 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:1bad217c-126e-4578-9823-8459abfbaadf | |
024 | 7 | a https://gup.ub.gu.se/publication/893492 URI |
024 | 7 | a https://doi.org/10.2337/db06-06002 DOI |
024 | 7 | a https://lup.lub.lu.se/record/6860242 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Huth, Cornelia4 aut |
245 | 1 0 | a IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies |
264 | 1 | b American Diabetes Association,c 2006 |
520 | a Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, −174G>C (rs1800795) and −573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 −174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 −573G>C and type 2 diabetes. The observed association of the IL6 −174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a body-mass index | |
653 | a interleukin-6 gene | |
653 | a tnf-alpha | |
653 | a -174 g/c | |
653 | a metaanalysis | |
653 | a mellitus | |
653 | a il-6 | |
653 | a association | |
653 | a c-174g | |
653 | a plasma | |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Vollmert, Caren4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Wolford, Johanna K.4 aut |
700 | 1 | a Langer, Birgit4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Hamid, Yasmin H.4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Meisinger, Christa4 aut |
700 | 1 | a Do?ring, Angela4 aut |
700 | 1 | a Lo?wel, Hannelore4 aut |
700 | 1 | a Lieb, Wolfgang4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Martin, Stephan4 aut |
700 | 1 | a Stephens, Jeffrey W.4 aut |
700 | 1 | a Ireland, Helen4 aut |
700 | 1 | a Mather, Hugh4 aut |
700 | 1 | a Miller, George J.4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Mo?hlig, Matthias4 aut |
700 | 1 | a Spranger, Joachim4 aut |
700 | 1 | a Pfeiffer, Andreas4 aut |
700 | 1 | a Wernstedt, Ingrid,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwerni |
700 | 1 | a Niklason, Anders,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk prövning och entreprenörskap,Institute of Medicine, Department of Clinical Trials and Entrepreneurship4 aut0 (Swepub:gu)xnandz |
700 | 1 | a Lo?pez-Bermejo, Abel4 aut |
700 | 1 | a Fernández-Real, José-Manuel4 aut |
700 | 1 | a Hanson, Robert L.4 aut |
700 | 1 | a Gallart, Luis4 aut |
700 | 1 | a Vendrell, Joan4 aut |
700 | 1 | a Tsiavou, Anastasia4 aut |
700 | 1 | a Hatziagelaki, Erifili4 aut |
700 | 1 | a Humphries, Steve E.4 aut |
700 | 1 | a Wichmann, H.-Erich4 aut |
700 | 1 | a Herder, Christian4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Doring, Angela4 aut |
700 | 1 | a Lowel, Hannelore4 aut |
700 | 1 | a Lopez-Bermejo, Abel4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t DIABETESd : American Diabetes Associationg 55:10, s. 2915-2921q 55:10<2915-2921x 0012-1797x 1939-327X |
856 | 4 | u http://diabetes.diabetesjournals.org/content/55/10/2915.full.pdf |
856 | 4 | u http://dx.doi.org/10.2337/db06-0600x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/89349 |
856 | 4 8 | u https://doi.org/10.2337/db06-0600 |
856 | 4 8 | u https://lup.lub.lu.se/record/686024 |
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