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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04033naa a2200481 4500 | |
| 001 | oai:gup.ub.gu.se/98783 | |
| 003 | SwePub | |
| 008 | 240910s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:120321227 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/987832 URI |
| 024 | 7 | a https://doi.org/10.1017/S00332917099908572 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1203212272 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Teodorczuk, A.4 aut |
| 245 | 1 0 | a Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study. |
| 264 | 1 | c 2009 |
| 520 | a BACKGROUND: Growing evidence suggests that cerebral white-matter changes and depressive symptoms are linked directly along the causal pathway. We investigated whether baseline severity of cerebral white-matter changes predict longer-term future depressive outcomes in a community sample of non-disabled older adults.MethodIn the Leukoaraiosis and Disability in the Elderly (LADIS) study, a longitudinal multi-centre pan-European study, 639 older subjects underwent baseline structural magnetic resonance imaging (MRI) and clinical assessments. Baseline severity of white-matter changes was quantified volumetrically. Depressive outcomes were assessed in terms of depressive episodes and depressive symptoms, as measured by the Geriatric Depression Scale (GDS). Subjects were clinically reassessed annually for up to 3 years. Regression models were constructed to determine whether baseline severity of white-matter changes predicted future depressive outcomes, after controlling for confounding factors. RESULTS: Baseline severity of white-matter changes independently predicted depressive symptoms at both 2 (p<0.001) and 3 years (p=0.015). Similarly, white-matter changes predicted incident depression (p=0.02). Over the study period the population became significantly more disabled (p<0.001). When regression models were adjusted to account for the influence of the prospective variable transition to disability, baseline severity of white-matter changes no longer predicted depressive symptoms at 3 years (p=0.09) or incident depression (p=0.08). CONCLUSIONS: Our results support the vascular depression hypothesis and strongly implicate white-matter changes in the pathogenesis of late-life depression. Furthermore, the findings indicate that, over time, part of the relationship between white-matter changes and depression may be mediated by loss of functional activity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 700 | 1 | a Firbank, M.J.4 aut |
| 700 | 1 | a Pantoni, L4 aut |
| 700 | 1 | a Poggesi, A4 aut |
| 700 | 1 | a Erkinjuntti, T4 aut |
| 700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand |
| 700 | 1 | a Wahlund, LOu Karolinska Institutet4 aut |
| 700 | 1 | a Scheltens, P4 aut |
| 700 | 1 | a Waldemar, G4 aut |
| 700 | 1 | a Schrotter, G4 aut |
| 700 | 1 | a Ferro, JM4 aut |
| 700 | 1 | a Chabriat,4 aut |
| 700 | 1 | a Bazner, H4 aut |
| 700 | 1 | a Visser, M4 aut |
| 700 | 1 | a Inzitari,4 aut |
| 700 | 1 | a O'Brien, JT4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Psychological medicineg 40:4, s. 603-610q 40:4<603-610x 1469-8978 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/98783 |
| 856 | 4 8 | u https://doi.org/10.1017/S0033291709990857 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120321227 |
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