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Sökning: onr:"swepub:oai:lup.lub.lu.se:00d5ad67-e55a-47ba-8a31-750866e6989b" > Use of the BOADICEA...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004538naa a2200529 4500
001oai:lup.lub.lu.se:00d5ad67-e55a-47ba-8a31-750866e6989b
003SwePub
008170811s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/00d5ad67-e55a-47ba-8a31-750866e6989b2 URI
0247 a https://doi.org/10.1007/s10689-017-0014-x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Brédart, Anneu Curie Institute, Paris,Paris Descartes University4 aut
2451 0a Use of the BOADICEA Web Application in clinical practice : appraisals by clinicians from various countries
264 c 2017-06-16
264 1b Springer Science and Business Media LLC,c 2018
520 a The ‘BOADICEA’ Web Application (BWA) used to assess breast cancer risk, is currently being further developed, to integrate additional genetic and non-genetic factors. We surveyed clinicians’ perceived acceptability of the existing BWA v3. An online survey was conducted through the BOADICEA website, and the British, Dutch, French and Swedish genetics societies. Cross-sectional data from 443 participants who provided at least 50% responses were analysed. Respondents varied in age and, clinical seniority, but mainly comprised women (77%) and genetics professionals (82%). Some expressed negative opinions about the scientific validity of BOADICEA (9%) and BWA v3 risk presentations (7–9%). Data entry time (62%), clinical utility (22%) and ease of communicating BWA v3 risks (13–17%) received additional negative appraisals. In multivariate analyses, controlling for gender and country, data entry time was perceived as longer by genetic counsellors than clinical geneticists (p < 0.05). Respondents who (1) considered hormonal BC risk factors as more important (p < 0.01), and (2) communicated numerical risk estimates more frequently (p < 0.001), judged BWA v3 of lower clinical utility. Respondents who carried out less frequent clinical activity (p < 0.01) and respondents with ‘11 to 15 years’ seniority (p < 0.01) had less favourable opinions of BWA v3 risk presentations. Seniority of ‘6 to 10 years’ (p < 0.05) and more frequent numerical risk communication (p < 0.05) were associated with higher fear of communicating the BWA v3 risks to patients. The level of genetics training did not affect opinions. Further development of BWA should consider technological, genetics service delivery and training initiatives.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Appraisal
653 a Breast cancer
653 a Clinical practice
653 a Risk prediction model
653 a Survey
653 a Tool
7001 a Kop, Jean Lucu University of Lorraine4 aut
7001 a Antoniou, Antonis C.u University of Cambridge4 aut
7001 a Cunningham, Alex P.u University of Cambridge4 aut
7001 a de Pauw, Antoineu Curie Institute, Paris4 aut
7001 a Tischkowitz, Marcu University of Cambridge4 aut
7001 a Ehrencrona, Hansu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-hen
7001 a Dolbeault, Sylvieu University of Paris-Saclay,Curie Institute, Paris4 aut
7001 a Robieux, Léonoreu Paris Descartes University4 aut
7001 a Rhiem, Kerstinu University Hospital of Cologne4 aut
7001 a Easton, Douglas F.u University of Cambridge4 aut
7001 a Devilee, Peteru Leiden University Medical Centre4 aut
7001 a Stoppa-Lyonnet, Dominiqueu Curie Institute, Paris4 aut
7001 a Schmutlzer, Ritau University Hospital of Cologne4 aut
7102 a Curie Institute, Parisb Paris Descartes University4 org
7730 t Familial Cancerd : Springer Science and Business Media LLCg 17:1, s. 31-41q 17:1<31-41x 1389-9600x 1573-7292
8564 u http://dx.doi.org/10.1007/s10689-017-0014-xx freey FULLTEXT
8564 u https://link.springer.com/content/pdf/10.1007%2Fs10689-017-0014-x.pdf
8564 8u https://lup.lub.lu.se/record/00d5ad67-e55a-47ba-8a31-750866e6989b
8564 8u https://doi.org/10.1007/s10689-017-0014-x

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