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Sökning: onr:"swepub:oai:lup.lub.lu.se:6627370c-299c-43d1-90d3-0b380d7cbbf9" > Anti-CA15.3 and Ant...

  • Cramer, Daniel W.Harvard University,Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)

Anti-CA15.3 and Anti-CA125 Antibodies and ovarian cancer risk : Results from the EPIC cohort

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research,2018
  • 15 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:6627370c-299c-43d1-90d3-0b380d7cbbf9
  • https://lup.lub.lu.se/record/6627370c-299c-43d1-90d3-0b380d7cbbf9URI
  • https://doi.org/10.1158/1055-9965.EPI-17-0744DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150744URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138657227URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Fichorova, Raina N.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)
  • Terry, Kathryn L.Brigham and Women's Hospital / Harvard Medical School,Harvard University (författare)
  • Yamamoto, HidemiBrigham and Women's Hospital / Harvard Medical School (författare)
  • Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Ardanaz, EvaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (författare)
  • Aune, DagfinnImperial College London (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Brandstedt, JennyLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jyb (författare)
  • Boutron-Ruault, Marie Christine (författare)
  • Chirlaque, Maria DoloresUniversity of Murcia (författare)
  • Dorronsoro, Miren (författare)
  • Dossus, LaureInternational Agency for Research on Cancer, World Health Organization (författare)
  • Duell, Eric J.Catalan Institute of Oncology (författare)
  • Gram, Inger T.UiT The Arctic University of Norway, Tromsø (författare)
  • Gunter, MarcInternational Agency for Research on Cancer, World Health Organization (författare)
  • Hansen, LouiseDanish Cancer Society (författare)
  • Idahl, Annika,1965-Umeå universitet,Umeå University,Obstetrik och gynekologi(Swepub:umu)anid0002 (författare)
  • Johnson, TheronGerman Cancer Research Centre (författare)
  • Khaw, Kay TeeUniversity of Cambridge (författare)
  • Krogh, VittorioIstituto Nazionale dei Tumori (författare)
  • Kvaskoff, Marina (författare)
  • Mattiello, AmaliaUniversity of Naples Federico II (författare)
  • Matullo, GiuseppeUniversity of Turin (författare)
  • Merritt, Melissa A.Imperial College London (författare)
  • Nodin, BjornLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)immu-bnn (författare)
  • Orfanos, PhilipposNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (författare)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht (författare)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (författare)
  • Peppa, EleniHellenic Health Foundation, Athens (författare)
  • Quiros, J. RamonPublic Health Directorate (författare)
  • Sanchez-Perez, Maria Jose (författare)
  • Severi, Gianluca (författare)
  • Tjønneland, AnneDanish Cancer Society (författare)
  • Travis, Ruth C.University of Oxford (författare)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (författare)
  • Tumino, Rosario (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research (författare)
  • Fortner, Renee T.German Cancer Research Centre (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • Harvard UniversityBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology Biomarkers and Prevention: American Association for Cancer Research27:7, s. 790-8041055-99651538-7755

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