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Sökning: onr:"swepub:oai:lup.lub.lu.se:75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2" > Osteopontin and dis...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010179naa a2201033 4500
001oai:lup.lub.lu.se:75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2
003SwePub
008190528s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-156906
009oai:prod.swepub.kib.ki.se:140803375
0247 a https://lup.lub.lu.se/record/75a564f3-2ebf-43ff-9b2b-49b0d3bb51e22 URI
0247 a https://doi.org/10.3899/jrheum.1807132 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1569062 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408033752 URI
040 a (SwePub)lud (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Wirestam, Lina,d 1986-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)linwi45
2451 0a Osteopontin and disease activity in patients with recent-onset systemic Lupus Erythematosus : Results from the SLICC Inception Cohort
264 c 2019-01-15
264 1b The Journal of Rheumatology,c 2019
500 a Funding Agencies|Swedish Rheumatism Association; County Council of Ostergotland; Swedish Society of Medicine; King Gustaf V and Queen Victorias Freemasons foundation; King Gustaf Vs 80-year anniversary foundation; Hanyang University [201600000001387]; Lupus UK; NIHR/Wellcome Trust Clinical Research Facility; US National Institutes of Health (NIH) [AR43727]; Singer Family Fund for Lupus Research; Arthritis Research UK; NIHR Manchester Biomedical Research Centre; NIHR/Wellcome Trust Clinical Research Facility at Manchester University National Health Service (NHS) Foundation Trust; Danish Rheumatism Association [A1028]; NIH [RR00046]
520 a Objective. In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Methods. We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available. All patients fulfilled the 1997 American College of Rheumatology (ACR) criteria. Baseline sera from patients and from age- and sex-matched population-based controls were analyzed for OPN using ELISA. Disease activity and damage were assessed at each annual followup visit using the SLE Disease Activity Index 2000 (SLEDAI-2K) and the SLICC/ACR damage index (SDI), respectively. Results. Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001). After relevant adjustments in a binary logistic regression model, OPN levels failed to significantly predict global damage accrual defined as SDI ≥ 1 at 5 years. However, baseline OPN correlated with SLEDAI-2K at enrollment into the cohort (r = 0.27, p < 0.0001), and patients with high disease activity (SLEDAI-2K ≥ 5) had raised serum OPN (p < 0.0001). In addition, higher OPN levels were found in patients with persistent disease activity (p = 0.0006), in cases with renal involvement (p < 0.0001) and impaired estimated glomerular filtration rate (p = 0.01). Conclusion. The performance of OPN to predict development of organ damage was not impressive. However, OPN associated significantly with lupus nephritis and with raised disease activity at enrollment, as well as over time.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Biomarkers
653 a Disease Activity
653 a Organ Damage
653 a Osteopontin
653 a Prognosis
653 a Systemic Lupus Erythematosus
653 a SYSTEMIC LUPUS ERYTHEMATOSUS; BIOMARKERS; OSTEOPONTIN; DISEASE ACTIVITY; ORGAN DAMAGE; PROGNOSIS
7001 a Enocsson, Helena,d 1982-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)helen05
7001 a Skogh, Thomas,d 1952-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)thosk00
7001 a Padyukov, Leonidu Karolinska Institutet4 aut
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)reum-ajo
7001 a Urowitz, Murray B.u University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada4 aut
7001 a Gladman, Dafna D.u University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada4 aut
7001 a Romero-DIaz, Juanitau Instituto Nacional de Ciencias Médicas y Nutrición,Inst Nacl Ciencias Med and Ntur, IL USA4 aut
7001 a Bae, Sang Cheolu Hanyang University Medical Center,Hanyang Univ Hosp Rheumat Dis, South Korea4 aut
7001 a Fortin, Paul R.u Laval University,Univ Laval, Canada4 aut
7001 a Sanchez-Guerrero, Jorgeu University of Toronto,Univ Toronto, Canada; Toronto Western Hosp, Canada4 aut
7001 a Clarke, Ann E.u University of Calgary,Univ Calgary, Canada4 aut
7001 a Bernatsky, Sashau McGill University Health Center,McGill Univ, Canada4 aut
7001 a Gordon, Carolineu University of Birmingham,Univ Birmingham, England4 aut
7001 a Hanly, John G.u Dalhousie University,Queen Elizabeth 2 Hlth Sci Ctr, Canada; Queen Elizabeth 2 Hlth Sci Ctr, Canada; Dalhousie Univ, Canada4 aut
7001 a Wallace, Danielu University of California, Los Angeles,Univ Calif Los Angeles, CA 90095 USA4 aut
7001 a Isenberg, David A.u University College London,UCL, England,Columbia Univ, NY USA4 aut
7001 a Rahman, Anisuru University College London,UCL, England4 aut
7001 a Merrill, Joanu Oklahoma Medical Research Foundation,Oklahoma Med Res Fdn, OK 73104 USA4 aut
7001 a Ginzler, Ellenu SUNY Downstate Health Sciences University,SUNY New York, NY USA4 aut
7001 a Alarcón, Graciela S.u University of Alabama,Univ Alabama Birmingham, AL 35294 USA4 aut
7001 a Chatham, W. Winnu University of Alabama,Univ Alabama Birmingham, AL 35294 USA4 aut
7001 a Petri, Michelleu Johns Hopkins University School of Medicine,Johns Hopkins Univ, MD USA4 aut
7001 a Khamashta, Muntheru University College London,St Thomas Hosp, England4 aut
7001 a Aranow, Cynthiau Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA4 aut
7001 a MacKay, Megganu Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA4 aut
7001 a Dooley, Mary Anneu University of North Carolina,Univ N Carolina, NC 27515 USA4 aut
7001 a Manzi, Susanu Allegheny Health Network,Autoimmun Inst, PA USA4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University,Northwestern Univ, IL USA; Feinberg Sch Med, IL USA4 aut
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden4 aut0 (Swepub:lu)reum-oni
7001 a Steinsson, Kristjanu Fossvogur Landspitali Univ Hosp, Iceland4 aut
7001 a Zoma, Asadu Hairmyres Hosp, Scotland4 aut
7001 a Ruiz-Irastorza, Guillermou University of the Basque Country,Univ Basque Country, Spain4 aut
7001 a Lim, Samu Emory University,Emory Univ, GA 30322 USA4 aut
7001 a Kalunian, Kenu Univ Calif San Diego, CA 92093 USA4 aut
7001 a Inanc, Muratu Istanbul Univ, Turkey4 aut
7001 a Van Vollenhoven, Ronaldu Karolinska Institutet4 aut
7001 a Ramos-Casals, Manuelu Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),IDIBAPS, Spain4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina,Med Univ South Carolina, SC 29425 USA4 aut
7001 a Jacobsen, Sørenu Copenhagen University Hospital,Copenhagen Univ Hosp, Denmark4 aut
7001 a Peschken, Christineu University of Manitoba,Univ Manitoba, Canada4 aut
7001 a Askanase, Ancau Columbia University4 aut
7001 a Stoll, Thomasu Kantousspital, Switzerland4 aut
7001 a Bruce, Ian N.u University of Manchester,Univ Manchester, England; Manchester Univ Fdn Trust, England4 aut
7001 a Wetterö, Jonas,d 1972-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)jonwe26
7001 a Sjöwall, Christoffer,d 1975-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)chrsj93
7102 a Linköping Universityb Avdelningen för neuro- och inflammationsvetenskap4 org
7730 t Journal of Rheumatologyd : The Journal of Rheumatologyg 46:5, s. 492-500q 46:5<492-500x 0315-162Xx 1499-2752
8564 u http://dx.doi.org/10.3899/jrheum.180713x freey FULLTEXT
8564 u https://www.jrheum.org/content/jrheum/46/5/492.full.pdf
8564 u https://doi.org/10.3899/jrheum.180713y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1318776/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2
8564 8u https://doi.org/10.3899/jrheum.180713
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156906
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140803375

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