Sökning: onr:"swepub:oai:lup.lub.lu.se:75e8f7e5-e8f9-48e9-83aa-ba1a139de0ec" > Deciphering the 8q2...
Fältnamn | Indikatorer | Metadata |
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000 | 04376naa a2200745 4500 | |
001 | oai:lup.lub.lu.se:75e8f7e5-e8f9-48e9-83aa-ba1a139de0ec | |
003 | SwePub | |
008 | 160401s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/39314432 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddt0632 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Enciso-Mora, Victor4 aut |
245 | 1 0 | a Deciphering the 8q24.21 association for glioma |
264 | c 2013-02-11 | |
264 | 1 | b Oxford University Press (OUP),c 2013 |
520 | a We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data generated on 253 individuals. Analysis revealed an imputed low-frequency SNP rs55705857 (P = 2.24 x 10(-38)) which was sufficient to fully capture the 8q24.21 association. Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 x 10(-67)). Validation of the non-GBM association was shown in three additional datasets (625 non-GBM cases, 2412 controls; P = 1.41 x 10(-28)). In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 x 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. These data provide additional insights into the aetiological basis of glioma development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Hosking, Fay J.4 aut |
700 | 1 | a Kinnersley, Ben4 aut |
700 | 1 | a Wang, Yufei4 aut |
700 | 1 | a Shete, Sanjay4 aut |
700 | 1 | a Zelenika, Diana4 aut |
700 | 1 | a Broderick, Peter4 aut |
700 | 1 | a Idbaih, Ahmed4 aut |
700 | 1 | a Delattre, Jean-Yves4 aut |
700 | 1 | a Hoang-Xuan, Khe4 aut |
700 | 1 | a Marie, Yannick4 aut |
700 | 1 | a Di Stefano, Anna Luisa4 aut |
700 | 1 | a Labussiere, Marianne4 aut |
700 | 1 | a Dobbins, Sara4 aut |
700 | 1 | a Boisselier, Blandine4 aut |
700 | 1 | a Ciccarino, Pietro4 aut |
700 | 1 | a Rossetto, Marta4 aut |
700 | 1 | a Armstrong, Georgina4 aut |
700 | 1 | a Liu, Yanhong4 aut |
700 | 1 | a Gousias, Konstantinos4 aut |
700 | 1 | a Schramm, Johannes4 aut |
700 | 1 | a Lau, Ching4 aut |
700 | 1 | a Hepworth, Sarah J.4 aut |
700 | 1 | a Strauch, Konstantin4 aut |
700 | 1 | a Mueller-Nurasyid, Martina4 aut |
700 | 1 | a Schreiber, Stefan4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Moebus, Susanne4 aut |
700 | 1 | a Eisele, Lewin4 aut |
700 | 1 | a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-asf |
700 | 1 | a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-khk |
700 | 1 | a Tomlinson, Ian P.4 aut |
700 | 1 | a Swerdlow, Anthony4 aut |
700 | 1 | a Lathrop, Mark4 aut |
700 | 1 | a Simon, Matthias4 aut |
700 | 1 | a Bondy, Melissa4 aut |
700 | 1 | a Sanson, Marc4 aut |
700 | 1 | a Houlston, Richard S.4 aut |
710 | 2 | a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 22:11, s. 2293-2302q 22:11<2293-2302x 0964-6906x 1460-2083 |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddt063y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc3652416?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/3931443 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddt063 |
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