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Sökning: onr:"swepub:oai:lup.lub.lu.se:81ca6bbf-7071-45ce-93a2-8055c6396c18" > The Four-Kallikrein...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004352naa a2200421 4500
001oai:lup.lub.lu.se:81ca6bbf-7071-45ce-93a2-8055c6396c18
003SwePub
008200715s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/81ca6bbf-7071-45ce-93a2-8055c6396c182 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-19-15602 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Darst, Burcu F.u University of Southern California4 aut
2451 0a The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population
264 1c 2020
300 a 8 s.
520 a BACKGROUND: The four-kallikrein (4K) panel has been demonstrated to improve prediction of aggressive prostate cancer compared with prostate-specific antigen (PSA) among men with moderately elevated PSA levels. However, the development and testing of the 4K panel has been conducted primarily in White men, with limited data in African Americans and no studies in other racial and ethnic groups. METHODS: We evaluated the 4K panel in a nested case-control study among African American, Latino, Japanese, Native Hawaiian, and White men in the Multiethnic Cohort. Prediagnostic blood levels of free, intact, and total PSA and human kallikrein-related peptidase 2 were measured among 1,667 incident prostate cancer cases and 691 controls with PSA ≥2 ng/mL. We evaluated the discriminative ability of the 4K panel within and across all racial/ethnic groups. RESULTS: The 4K panel enhanced discrimination of overall prostate cancer compared with free plus total PSA and total PSA alone (AUC 0.748 vs. 0.711 and 0.669, respectively). Discrimination was further enhanced for Gleason 8+ prostate cancer, aggressive prostate cancer, and death due to prostate cancer, and to a lesser degree for nonaggressive prostate cancer. Improvement of the 4K panel over PSA was observed in each population. Adding a prostate cancer polygenic risk score slightly improved upon the discriminative ability of the 4K panel. CONCLUSIONS: The superior discriminative ability of the 4K panel over PSA for overall and aggressive prostate cancer across multiethnic populations indicates the broad clinical applicability of the 4K panel. IMPACT: Our multiethnic investigation suggests potential for the 4K panel to improve current prostate cancer screening practices.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Chou, Alishau University of Southern California4 aut
7001 a Wan, Peggyu University of Southern California4 aut
7001 a Pooler, Loreallu University of Southern California4 aut
7001 a Sheng, Xinu University of Southern California4 aut
7001 a Vertosick, Emily A.u Memorial Sloan-Kettering Cancer Center4 aut
7001 a Conti, David V.u University of Southern California4 aut
7001 a Wilkens, Lynne R.u University of Hawai'i at Hilo4 aut
7001 a Le Marchand, Loïcu University of Hawai'i at Hilo4 aut
7001 a Vickers, Andrew J.u Memorial Sloan-Kettering Cancer Center4 aut
7001 a Lilja, Hans G.u Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center4 aut0 (Swepub:lu)klke-hli
7001 a Haiman, Christopher A.u University of Southern California4 aut
7102 a University of Southern Californiab Memorial Sloan-Kettering Cancer Center4 org
7730 t Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyg 29:7, s. 1381-1388q 29:7<1381-1388x 1538-7755
8564 u http://dx.doi.org/10.1158/1055-9965.EPI-19-1560y FULLTEXT
8564 8u https://lup.lub.lu.se/record/81ca6bbf-7071-45ce-93a2-8055c6396c18
8564 8u https://doi.org/10.1158/1055-9965.EPI-19-1560

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