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FältnamnIndikatorerMetadata
00008753naa a2200769 4500
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003SwePub
008160401s2007 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/60243
009oai:DiVA.org:umu-6142
009oai:DiVA.org:uu-16993
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009oai:DiVA.org:liu-42527
024a https://lup.lub.lu.se/record/6879352 URI
024a https://doi.org/10.1210/jc.2007-04582 DOI
024a https://gup.ub.gu.se/publication/602432 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61422 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169932 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1158261802 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-425272 URI
040 a (SwePub)lud (SwePub)gud (SwePub)umud (SwePub)uud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Holmer, Heleneu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Centralsjukhuset, Kristianstad, Sweden4 aut0 (Swepub:lu)med-hho
2451 0a Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone
264 1b The Endocrine Society,c 2007
520 a Context: The impact of long-term GH replacement on cerebrovascular and cardiovascular diseases and diabetes mellitus in hypopituitary patients is unknown. Objective: The incidence of nonfatal stroke and cardiac events, and prevalence of type 2 diabetes mellitus ( T2D) and cardioprotective medication were compared between cohorts of GH-deficient (GHD) patients and population controls. Design and Participants: The incidence of nonfatal stroke and cardiac events was estimated retrospectively from questionnaires in 750 GHD patients and 2314 matched population controls. A prevalence of T2D and cardioprotective medication was recorded at the distribution of questionnaires. Time since first pituitary deficiency to start of GH therapy was 4 and 2 yr, and time on GH therapy was 6 yr for GHD women and men, respectively. Results: Lifelong incidence of nonfatal stroke was tripled in GHD women and doubled in GHD men, but a decline was seen in both genders during periods after first pituitary hormone deficiency and GHD, during which most patients had GH therapy. The lifelong incidence of nonfatal cardiac events declined in GHD men during first pituitary hormone deficiency and GHD periods. GHD women had a higher prevalence of T2D and lipid-lowering medication, whereas GHD men had a higher prevalence of antihypertensive medication. Conclusions: The declined risks of nonfatal stroke in both genders and of nonfatal cardiac events in GHD men during periods on GH replacement may be caused by prescription of cardioprotective drugs and 6-yr GH replacement. GHD women had an increased prevalence of T2D, partly attributed to higher body mass index and lower physical activity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a MEDICINE
700a Svensson, Johanu Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital, Göteborg, Sweden4 aut0 (Swepub:gu)xsjohc
700a Rylander, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)ymed-lry
700a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital, Göteborg, Sweden4 aut0 (Swepub:gu)xjgudn
700a Rosén, Thord,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrenska University Hospital, Göteborg, Sweden4 aut0 (Swepub:gu)xrosth
700a Bengtsson, Bengt-Åke,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital, Göteborg, Sweden4 aut0 (Swepub:gu)xbenbe
700a Thorén, Marjau Karolinska Institutet,Karolinska University Hospital Solna, Stockholm, Sweden4 aut
700a Hoybye, Charlotteu Karolinska Institutet,Karolinska University Hospital Solna, Stockholm, Sweden4 aut
700a Degerblad, Marieu Karolinska Institutet,Karolinska University Hospital Solna, Stockholm, Sweden4 aut
700a Bramnert, Margaretau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,University Hospital, Malmö, Sweden4 aut0 (Swepub:lu)endo-mbr
700a Hägg, Eriku University Hospital, Umeå, Sweden4 aut0 (Swepub:umu)erha0014
700a Edén Engström, Brittu Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism,Uppsala University Hospital, Sweden4 aut0 (Swepub:uu)brittee
700a Ekman, Bertil,d 1958-u Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US4 aut0 (Swepub:liu)berek83
700a Norrving, Bou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital, Sweden4 aut0 (Swepub:lu)neur-bno
700a Hagmar, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)ymed-lha
700a Erfurth, Eva Marieu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital, Sweden4 aut0 (Swepub:lu)med-ee0
710a Medicin, Lundb Sektion II4 org
773t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 92:9, s. 3560-3567q 92:9<3560-3567x 1945-7197x 0021-972X
856u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17623762&dopt=Abstractx freey FULLTEXT
856u http://dx.doi.org/10.1210/jc.2007-0458x freey FULLTEXT
856u https://academic.oup.com/jcem/article-pdf/92/9/3560/10405524/jcem3560.pdf
8564 8u https://lup.lub.lu.se/record/687935
8564 8u https://doi.org/10.1210/jc.2007-0458
8564 8u https://gup.ub.gu.se/publication/60243
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6142
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16993
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:115826180
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-42527

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