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Search: onr:"swepub:oai:lup.lub.lu.se:d35d31e7-399a-45bb-910f-acc17762fa09" > Underlying Genetic ...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004644naa a2200757 4500
001oai:lup.lub.lu.se:d35d31e7-399a-45bb-910f-acc17762fa09
003SwePub
008160401s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/14770822 URI
0247 a https://doi.org/10.1093/aje/kwp1452 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Salanti, Georgia4 aut
2451 0a Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
264 c 2009-07-14
264 1b Oxford University Press (OUP),c 2009
520 a For most associations of common single nucleotide polymorphisms (SNPs) with common diseases, the genetic model of inheritance is unknown. The authors extended and applied a Bayesian meta-analysis approach to data from 19 studies on 17 replicated associations with type 2 diabetes. For 13 SNPs, the data fitted very well to an additive model of inheritance for the diabetes risk allele; for 4 SNPs, the data were consistent with either an additive model or a dominant model; and for 2 SNPs, the data were consistent with an additive or recessive model. Results were robust to the use of different priors and after exclusion of data for which index SNPs had been examined indirectly through proxy markers. The Bayesian meta-analysis model yielded point estimates for the genetic effects that were very similar to those previously reported based on fixed- or random-effects models, but uncertainty about several of the effects was substantially larger. The authors also examined the extent of between-study heterogeneity in the genetic model and found generally small between-study deviation values for the genetic model parameter. Heterosis could not be excluded for 4 SNPs. Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Bayes theorem
653 a type 2
653 a meta-analysis
653 a models
653 a polymorphism
653 a genetic
653 a diabetes mellitus
653 a population characteristics
7001 a Southam, Lorraine4 aut
7001 a Altshuler, David4 aut
7001 a Ardlie, Kristin4 aut
7001 a Barroso, Ines4 aut
7001 a Boehnke, Michael4 aut
7001 a Cornelis, Marilyn C.4 aut
7001 a Frayling, Timothy M.4 aut
7001 a Grallert, Harald4 aut
7001 a Grarup, Niels4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Hansen, Torben4 aut
7001 a Hattersley, Andrew T.4 aut
7001 a Hu, Frank B.4 aut
7001 a Hveem, Kristian4 aut
7001 a Illig, Thomas4 aut
7001 a Kuusisto, Johanna4 aut
7001 a Laakso, Markku4 aut
7001 a Langenberg, Claudia4 aut
7001 a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
7001 a McCarthy, Mark I.4 aut
7001 a Morris, Andrew4 aut
7001 a Morris, Andrew D.4 aut
7001 a Palmer, Colin N. A.4 aut
7001 a Payne, Felicity4 aut
7001 a Platou, Carl G. P.4 aut
7001 a Scott, Laura J.4 aut
7001 a Voight, Benjamin F.4 aut
7001 a Wareham, Nicholas J.4 aut
7001 a Zeggini, Eleftheria4 aut
7001 a Ioannidis, John P. A.4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t American Journal of Epidemiologyd : Oxford University Press (OUP)g 170:5, s. 537-545q 170:5<537-545x 0002-9262x 1476-6256
8564 u http://dx.doi.org/10.1093/aje/kwp145x freey FULLTEXT
8564 u https://academic.oup.com/aje/article-pdf/170/5/537/17338086/kwp145.pdf
8564 8u https://lup.lub.lu.se/record/1477082
8564 8u https://doi.org/10.1093/aje/kwp145

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