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Sökning: onr:"swepub:oai:lup.lub.lu.se:d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9" > Second primary canc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005150naa a2200457 4500
001oai:lup.lub.lu.se:d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9
003SwePub
008181023s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee92 URI
0247 a https://doi.org/10.1002/ijc.318012 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Chattopadhyay, Subhayanu German Cancer Research Centre,Heidelberg University4 aut0 (Swepub:lu)su1252ch
2451 0a Second primary cancers in non-Hodgkin lymphoma : Bidirectional analyses suggesting role for immune dysfunction
264 c 2018-09-21
264 1b Wiley,c 2018
520 a Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 individuals with primary NHL diagnosed between 1993 and 2015. We calculated relative risks (RRs) of SPCs in NHL survivors and, for bi-directional analysis, risk of NHL as SPC. The overall RRs were significantly bidirectionally increased for NHL and 7 cancers. After diagnosis of NHL risks were increased for upper aerodigestive tract (RR = 1.96), colorectal (1.35), kidney (3.10), bladder (1.54) and squamous cell skin cancer (SCC) (4.12), melanoma (1.98) and Hodgkin lymphoma (9.38). The concordance between RRs for each bidirectional association between NHL and 31 different cancers was highly significant (r = 0.86, p < 0.0001). Melanoma was bidirectionally associated with all 10 subtypes of NHL. The observed bidirectional associations between NHL and cancer suggest that therapy-related carcinogenic mechanisms cannot solely explain the findings. Considering that skin SCC and melanoma are usually treated by surgery and that these cancers and NHL are most responsive of any cancer to immune suppression, the consistent bidirectional results provide population-level evidence that immune suppressed state is a key underlying mechanism in the context of SPCs. Furthermore, the quantified risks for NHL subtypes have direct clinical application in the management of NHL patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a bi-directional risk
653 a immune suppression
653 a second cancers
653 a therapeutic implication
7001 a Sud, Amitu Institute of Cancer Research London,German Cancer Research Centre4 aut0 (Swepub:lu)am6750su
7001 a Zheng, Guoqiaou Heidelberg University,German Cancer Research Centre4 aut0 (Swepub:lu)gu4135zh
7001 a Yu, Hongyaou German Cancer Research Centre,Heidelberg University4 aut0 (Swepub:lu)med-hgy
7001 a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Center for Primary Health Care Research,Icahn School of Medicine at Mount Sinai,Shimane University4 aut0 (Swepub:lu)med-ksq
7001 a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-jsu
7001 a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-asf
7001 a Houlston, Richardu Institute of Cancer Research London4 aut
7001 a Hemminki, Akseliu University of Helsinki,Helsinki University Central Hospital4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research,German Cancer Research Centre4 aut0 (Swepub:lu)med-khk
7102 a German Cancer Research Centreb Heidelberg University4 org
7730 t International Journal of Cancerd : Wileyg 143:10, s. 2449-2457q 143:10<2449-2457x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.31801y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31801
8564 8u https://lup.lub.lu.se/record/d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9
8564 8u https://doi.org/10.1002/ijc.31801

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