Sökning: onr:"swepub:oai:lup.lub.lu.se:e24186cf-b864-4612-9009-34dafc946a18" > Genome-wide meta-an...
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000 | 08145naa a2201705 4500 | |
001 | oai:lup.lub.lu.se:e24186cf-b864-4612-9009-34dafc946a18 | |
003 | SwePub | |
008 | 160401s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/16191892 URI |
024 | 7 | a https://doi.org/10.1038/ng.5712 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Furberg, Helena4 aut |
245 | 1 0 | a Genome-wide meta-analyses identify multiple loci associated with smoking behavior |
264 | c 2010-04-25 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
520 | a Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Kim, YunJung4 aut |
700 | 1 | a Dackor, Jennifer4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Ardissino, Diego4 aut |
700 | 1 | a Bernardinelli, Luisa4 aut |
700 | 1 | a Mannucci, Pier M.4 aut |
700 | 1 | a Mauri, Francesco4 aut |
700 | 1 | a Merlini, Piera A.4 aut |
700 | 1 | a Absher, Devin4 aut |
700 | 1 | a Assimes, Themistocles L.4 aut |
700 | 1 | a Fortmann, Stephen P.4 aut |
700 | 1 | a Iribarren, Carlos4 aut |
700 | 1 | a Knowles, Joshua W.4 aut |
700 | 1 | a Quertermous, Thomas4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Furberg, Curt D.4 aut |
700 | 1 | a Haritunians, Talin4 aut |
700 | 1 | a McKnight, Barbara4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Taylor, Kent D.4 aut |
700 | 1 | a Thacker, Evan L.4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Benjamin, Emelia J.4 aut |
700 | 1 | a Hwang, Shih-Jen4 aut |
700 | 1 | a Levy, Daniel4 aut |
700 | 1 | a Preis, Sarah Rosner4 aut |
700 | 1 | a Vasan, Ramachandran S.4 aut |
700 | 1 | a Duan, Jubao4 aut |
700 | 1 | a Gejman, Pablo V.4 aut |
700 | 1 | a Levinson, Douglas F.4 aut |
700 | 1 | a Sanders, Alan R.4 aut |
700 | 1 | a Shi, Jianxin4 aut |
700 | 1 | a Lips, Esther H.4 aut |
700 | 1 | a Mckay, James D.4 aut |
700 | 1 | a Agudo, Antonio4 aut |
700 | 1 | a Barzan, Luigi4 aut |
700 | 1 | a Bencko, Vladimir4 aut |
700 | 1 | a Benhamou, Simone4 aut |
700 | 1 | a Castellsague, Xavier4 aut |
700 | 1 | a Canova, Cristina4 aut |
700 | 1 | a Conway, David I.4 aut |
700 | 1 | a Fabianova, Eleonora4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Healy, Claire M.4 aut |
700 | 1 | a Holcatova, Ivana4 aut |
700 | 1 | a Kjaerheim, Kristina4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Lowry, Ray4 aut |
700 | 1 | a Macfarlane, Tatiana V.4 aut |
700 | 1 | a Mates, Dana4 aut |
700 | 1 | a Richiardi, Lorenzo4 aut |
700 | 1 | a Rudnai, Peter4 aut |
700 | 1 | a Szeszenia-Dabrowska, Neonilia4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Znaor, Ariana4 aut |
700 | 1 | a Lathrop, Mark4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Frayling, Timothy M.4 aut |
700 | 1 | a Guralnik, Jack M.4 aut |
700 | 1 | a Milaneschi, Yuri4 aut |
700 | 1 | a Perry, John R. B.4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Elosua, Roberto4 aut |
700 | 1 | a Kathiresan, Sek4 aut |
700 | 1 | a Lucas, Gavin4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Schwartz, Stephen M.4 aut |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Penninx, Brenda W.4 aut |
700 | 1 | a Smit, Johannes H.4 aut |
700 | 1 | a Vogelzangs, Nicole4 aut |
700 | 1 | a Boomsma, Dorret I.4 aut |
700 | 1 | a de Geus, Eco J. C.4 aut |
700 | 1 | a Vink, Jacqueline M.4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Gu, Fangyi4 aut |
700 | 1 | a Hankinson, Susan E.4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Tiemeier, Henning4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Walter, Stefan4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Everett, Brendan M.4 aut |
700 | 1 | a Pare, Guillaume4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Li, Ming D.4 aut |
700 | 1 | a Maes, Hermine H.4 aut |
700 | 1 | a Audrain-McGovern, Janet4 aut |
700 | 1 | a Posthuma, Danielle4 aut |
700 | 1 | a Thornton, Laura M.4 aut |
700 | 1 | a Lerman, Caryn4 aut |
700 | 1 | a Kaprio, Jaakko4 aut |
700 | 1 | a Rose, Jed E.4 aut |
700 | 1 | a Ioannidis, John P. A.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Lin, Dan-Yu4 aut |
700 | 1 | a Sullivan, Patrick F.4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:5, s. 134-441q 42:5<134-441x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.571y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc2914600?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/1619189 |
856 | 4 8 | u https://doi.org/10.1038/ng.571 |
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