Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease

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Fältnamn	Indikatorer	Metadata
000		04179naa a2200745 4500
001		oai:lup.lub.lu.se:e956cbb6-27b2-4b6b-b665-4b9a84b62883
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:129547395
024	7	a https://lup.lub.lu.se/record/46625692 URI
024	7	a https://doi.org/10.1002/mds.258412 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1295473952 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Chung, Sun Ju4 aut
245	1 0	a Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease
264		c 2014-02-27
264	1	b Wiley,c 2014
520		a Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653		a Parkinson's disease
653		a alpha-synuclein
653		a gene
653		a survival
653		a association
700	1	a Biernacka, Joanna M.4 aut
700	1	a Armasu, Sebastian M.4 aut
700	1	a Anderson, Kari4 aut
700	1	a Frigerio, Roberta4 aut
700	1	a Aasly, Jan O.4 aut
700	1	a Annesi, Grazia4 aut
700	1	a Bentivoglio, Anna Rita4 aut
700	1	a Brighina, Laura4 aut
700	1	a Chartier-Harlin, Marie-Christine4 aut
700	1	a Goldwurm, Stefano4 aut
700	1	a Hadjigeorgiou, Georgios4 aut
700	1	a Jasinska-Myga, Barbara4 aut
700	1	a Jeon, Beom Seok4 aut
700	1	a Kim, Yun Joong4 aut
700	1	a Krueger, Rejko4 aut
700	1	a Lesage, Suzanne4 aut
700	1	a Markopoulou, Katerina4 aut
700	1	a Mellick, George4 aut
700	1	a Morrison, Karen E.4 aut
700	1	a Puschmann, Andreasu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-aps
700	1	a Tan, Eng-King4 aut
700	1	a Crosiers, David4 aut
700	1	a Theuns, Jessie4 aut
700	1	a Van Broeckhoven, Christine4 aut
700	1	a Wirdefeldt, Karinu Karolinska Institutet4 aut
700	1	a Wszolek, Zbigniew K.4 aut
700	1	a Elbaz, Alexis4 aut
700	1	a Maraganore, Demetrius M.4 aut
710	2	a Neurologi, Lundb Sektion IV4 org
773	0	t Movement Disordersd : Wileyg 29:8, s. 1053-1057q 29:8<1053-1057x 0885-3185
773	0	t Movement disorders : official journal of the Movement Disorder Societyd : Wileyg 29:8, s. 1053-1057q 29:8<1053-1057x 1531-8257
856	4	u http://dx.doi.org/10.1002/mds.25841y FULLTEXT
856	4	u https://research-repository.griffith.edu.au/bitstream/10072/67744/1/MellickPUB30.pdf
856	4 8	u https://lup.lub.lu.se/record/4662569
856	4 8	u https://doi.org/10.1002/mds.25841
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:129547395

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