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onr:"swepub:oai:prod.swepub.kib.ki.se:124109838"
 

Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:124109838" > Association study b...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002213naa a2200373 4500
001oai:prod.swepub.kib.ki.se:124109838
003SwePub
008240415s2012 | |||||||||||000 ||eng|
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1241098382 URI
024a https://doi.org/10.1590/s0004-282x20120002000032 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Cappi, C4 aut
2451 0a Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
264 1b FapUNIFESP (SciELO),c 2012
520 a Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.
700a Muniz, RK4 aut
700a Sampaio, AS4 aut
700a Cordeiro, Q4 aut
700a Brentani, H4 aut
700a Palacios, SA4 aut
700a Marques, AH4 aut
700a Vallada, Hu Karolinska Institutet4 aut
700a Miguel, EC4 aut
700a Guilherme, L4 aut
700a Hounie, AG4 aut
710a Karolinska Institutet4 org
773t Arquivos de neuro-psiquiatriad : FapUNIFESP (SciELO)g 70:2, s. 87-90q 70:2<87-90x 1678-4227x 0004-282X
856u http://www.scielo.br/pdf/anp/v70n2/a03v70n2.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124109838
8564 8u https://doi.org/10.1590/s0004-282x2012000200003

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