Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:124109838" > Association study b...
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000 | 02213naa a2200373 4500 | |
001 | oai:prod.swepub.kib.ki.se:124109838 | |
003 | SwePub | |
008 | 240415s2012 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1241098382 URI |
024 | 7 | a https://doi.org/10.1590/s0004-282x20120002000032 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Cappi, C4 aut |
245 | 1 0 | a Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder |
264 | 1 | b FapUNIFESP (SciELO),c 2012 |
520 | a Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis. | |
700 | 1 | a Muniz, RK4 aut |
700 | 1 | a Sampaio, AS4 aut |
700 | 1 | a Cordeiro, Q4 aut |
700 | 1 | a Brentani, H4 aut |
700 | 1 | a Palacios, SA4 aut |
700 | 1 | a Marques, AH4 aut |
700 | 1 | a Vallada, Hu Karolinska Institutet4 aut |
700 | 1 | a Miguel, EC4 aut |
700 | 1 | a Guilherme, L4 aut |
700 | 1 | a Hounie, AG4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Arquivos de neuro-psiquiatriad : FapUNIFESP (SciELO)g 70:2, s. 87-90q 70:2<87-90x 1678-4227x 0004-282X |
856 | 4 | u http://www.scielo.br/pdf/anp/v70n2/a03v70n2.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124109838 |
856 | 4 8 | u https://doi.org/10.1590/s0004-282x2012000200003 |
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