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MicroRNA-132 promot...
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Li, XKarolinska Institutet
(författare)
MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-08-10
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Springer Science and Business Media LLC,2017
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:136396213
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136396213URI
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https://doi.org/10.1038/s41598-017-07513-0DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421665URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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MicroRNA (miR)-132 has been identified as a top up-regulated miRNA during skin wound healing and its inhibition impairs wound repair. In a human in vivo surgical wound model, we showed that miR-132 was induced in epidermal as well as in dermal wound–edge compartments during healing. Moreover, in a panel of cells isolated from human skin wounds, miR-132 was found highly expressed in human dermal fibroblasts (HDFs). In HDFs, miR-132 expression was upregulated by TGF-β1. By overexpression or inhibition of miR-132, we showed that miR-132 promoted HDF migration. Mechanistically, global transcriptome analysis revealed that RAS signaling pathway was regulated by miR-132 in HDFs. We found that RAS p21 protein activator 1 (RASA1), a known target of miR-132, was downregulated in HDFs upon miR-132 overexpression. Silencing of RASA1 phenocopied the pro-migratory effect of miR-132. Collectively, our study reveals an important role for miR-132 in HDFs during wound healing and indicates a therapeutic potential of miR-132 in hard-to-heal skin wounds.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Li, DQKarolinska Institutet
(författare)
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Wikstrom, JDKarolinska Institutet
(författare)
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Pivarcsi, AndorKarolinska Institutet(Swepub:uu)andpi932
(författare)
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Sonkoly, EniköKarolinska Institutet(Swepub:uu)enipi547
(författare)
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Stahle, MKarolinska Institutet
(författare)
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Landen, NXKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific reports: Springer Science and Business Media LLC7:1, s. 7797-2045-2322
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