Tyck till om SwePub Sök här!
onr:"swepub:oai:prod.swepub.kib.ki.se:136396213"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:136396213" > MicroRNA-132 promot...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Li, XKarolinska Institutet (author)
MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-08-10
- Springer Science and Business Media LLC,2017
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:136396213
- http://kipublications.ki.se/Default.aspx?queryparsed=id:136396213URI
- https://doi.org/10.1038/s41598-017-07513-0DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421665URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- MicroRNA (miR)-132 has been identified as a top up-regulated miRNA during skin wound healing and its inhibition impairs wound repair. In a human in vivo surgical wound model, we showed that miR-132 was induced in epidermal as well as in dermal wound–edge compartments during healing. Moreover, in a panel of cells isolated from human skin wounds, miR-132 was found highly expressed in human dermal fibroblasts (HDFs). In HDFs, miR-132 expression was upregulated by TGF-β1. By overexpression or inhibition of miR-132, we showed that miR-132 promoted HDF migration. Mechanistically, global transcriptome analysis revealed that RAS signaling pathway was regulated by miR-132 in HDFs. We found that RAS p21 protein activator 1 (RASA1), a known target of miR-132, was downregulated in HDFs upon miR-132 overexpression. Silencing of RASA1 phenocopied the pro-migratory effect of miR-132. Collectively, our study reveals an important role for miR-132 in HDFs during wound healing and indicates a therapeutic potential of miR-132 in hard-to-heal skin wounds.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Li, DQKarolinska Institutet (author)
- Wikstrom, JDKarolinska Institutet (author)
- Pivarcsi, AndorKarolinska Institutet(Swepub:uu)andpi932 (author)
- Sonkoly, EniköKarolinska Institutet(Swepub:uu)enipi547 (author)
- Stahle, MKarolinska Institutet (author)
- Landen, NXKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Scientific reports: Springer Science and Business Media LLC7:1, s. 7797-2045-2322
Internet link
Find in a library
- Scientific reports (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Li, X
- Li, DQ
- Wikstrom, JD
- Pivarcsi, Andor
- Sonkoly, Enikö
- Stahle, M
- show more...
- Landen, NX
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Dermatology and ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Scientific repor ...
- By the university
- Karolinska Institutet
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
