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Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:143805345" > Beyond the Epilepti...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003014naa a2200433 4500
001oai:prod.swepub.kib.ki.se:143805345
003SwePub
008240415s2020 | |||||||||||000 ||eng|
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1438053452 URI
024a https://doi.org/10.1093/cercor/bhz2432 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Gil, F4 aut
2451 0a Beyond the Epileptic Focus: Functional Epileptic Networks in Focal Epilepsy
264 c 2019-12-21
264 1b Oxford University Press (OUP),c 2020
520 a Focal epilepsy can be conceptualized as a network disorder, and the functional epileptic network can be described as a complex system of multiple brain areas that interact dynamically to generate epileptic activity. However, we still do not fully understand the functional architecture of epileptic networks. We studied a cohort of 21 patients with extratemporal focal epilepsy. We used independent component analysis of functional magnetic resonance imaging (fMRI) data. In order to identify the epilepsy-related components, we examined the general linear model-derived electroencephalography-fMRI (EEG–fMRI) time courses associated with interictal epileptic activity as intrinsic hemodynamic epileptic biomarkers. Independent component analysis revealed components related to the epileptic time courses in all 21 patients. Each epilepsy-related component described a network of spatially distributed brain areas that corresponded to the specific epileptic network in each patient. We also provided evidence for the interaction between the epileptic activity generated at the epileptic network and the physiological resting state networks. Our findings suggest that independent component analysis, guided by EEG–fMRI epileptic time courses, have the potential to define the functional architecture of the epileptic network in a noninvasive way. These data could be useful in planning invasive EEG electrode placement, guiding surgical resections, and more effective therapeutic interventions.
700a Padilla, Nu Karolinska Institutet4 aut
700a Soria-Pastor, S4 aut
700a Setoain, X4 aut
700a Boget, T4 aut
700a Rumia, J4 aut
700a Roldan, P4 aut
700a Reyes, D4 aut
700a Bargallo, N4 aut
700a Conde, E4 aut
700a Pintor, L4 aut
700a Vernet, O4 aut
700a Manzanares, I4 aut
700a Aden, Uu Karolinska Institutet4 aut
700a Carreno, M4 aut
700a Donaire, A4 aut
710a Karolinska Institutet4 org
773t Cerebral cortex (New York, N.Y. : 1991)d : Oxford University Press (OUP)g 30:4, s. 2338-2357q 30:4<2338-2357x 1460-2199x 1047-3211
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143805345
8564 8u https://doi.org/10.1093/cercor/bhz243

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