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Association Between...
Association Between Polymorphisms in the Dopamine Transporter Gene and Depression : Evidence for a Gene-Environment Interaction in a Sample of Juvenile Detainees
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Haeffel, Gerald J. (author)
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Getchell, Marya (author)
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Koposov, Roman A. (author)
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Yrigollen, Carolyn M. (author)
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DeYoung, Colin (author)
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- af Klinteberg, Britt (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),Psykologiska institutionen
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- Oreland, Lars (author)
- Uppsala universitet,Farmakologi
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- Ruchkin, Vladislav V. (author)
- Karolinska Institutet
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Grigorenko, Elena L. (author)
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(creator_code:org_t)
- 2008-01-01
- 2008
- English.
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In: Psychological Science. - : SAGE Publications. - 0956-7976 .- 1467-9280. ; 19:1, s. 62-69
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G × E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N= 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G × E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- polymorphisms
- dopamine transporter gene
- depression
- juvenile detainees
- Psychology
- Psykologi
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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