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Separation of rat l...
Separation of rat leukocytes by countercurrent distribution in aqueous two-phase systems. II. Subpopulations which mediate selective and nonselective lysis of normal and colon carcinoma target cells in vitro
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- Nelson, K (författare)
- Lund University
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- Malmström, P (författare)
- Lund University,Lunds universitet,Wallenberglaboratoriet, Lund,Medicinska fakulteten,The Wallenberg Laboratory,Faculty of Medicine
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- Jönsson, Å (författare)
- Lund University
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- Sjögren, H O (författare)
- Lund University
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(creator_code:org_t)
- Elsevier BV, 1978
- 1978
- Engelska.
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Ingår i: Cellular Immunology. - : Elsevier BV. - 0008-8749. ; 37:2, s. 422-431
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Spleen cells from WF rats immunized to allogeneic lymphoid cells or to syngeneic colon carcinomas and from unimmunized controls were separated by countercurrent distribution in aqueous two-phase systems. The cells were assayed for cytotoxicity to allogeneic fibroblasts or syngeneic colon carcinoma cells and to syngeneic fibroblasts in a 24-hr 51Cr-release assay. Cells from immunized rats which selectively lysed the specific target cells were repeatedly found in one area of the distribution separate from the majority of cells, which nonselectively lysed syngeneic fibroblasts as well. A similar subpopulation which nonselectively lysed all target cells assayed was recovered from the spleens of unimmunized rats. The cells were also assayed for the ability to lyse antibody-coated thymocytes in a 4-hr 51Cr-release assay. The peak of K cells was found to overlap partially that of cells with nonselective cytotoxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Animals
- Carcinoma/immunology
- Cell Line
- Cell Separation
- Colonic Neoplasms/immunology
- Countercurrent Distribution
- Cytotoxicity, Immunologic
- Female
- Leukocytes/cytology
- Neoplasms, Experimental/immunology
- Rats
- Rats, Inbred BN
- Rats, Inbred WF
- Spleen/immunology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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