Sökning: AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology)
> (1985-1989)
> (1986) >
Demonstration of an...
Demonstration of antibodies binding to autologous and allogeneic leukemic cells in childhood ALL - Evidence for a common ALL antigen(s)
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- Fäldt, R. (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberglaboratoriet, Lund,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,The Wallenberg Laboratory
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- Ankerst, J. (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberglaboratoriet, Lund,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,The Wallenberg Laboratory
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- Garwicz, S. (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 1986
- 1986
- Engelska.
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Ingår i: Blut. - 0006-5242. ; 52:6, s. 337-343
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a 125I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- I protein A binding assay
- Acute lymphoblastic leukemia
- Antibodies
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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