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Prevention of oral ...
Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations-a feasibility study and randomized controlled trial
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- Kamsvåg, Tove, 1986- (author)
- Uppsala universitet,Uppsala University,Institutionen för kvinnors och barns hälsa
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- Svanberg, Anncarin, 1956- (author)
- Uppsala universitet,Uppsala University,Vårdvetenskap
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- Legert, K. G. (author)
- Karolinska Institutet,Karolinska Institute,Department of Dental Medicine, Karolinska Institutet
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- Arvidson, Johan, 1953- (author)
- Uppsala universitet,Uppsala University,Barnneurologi/Barnonkologi
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- von Essen, Louise, 1957- (author)
- Uppsala universitet,Uppsala University,Klinisk psykologi i hälso- och sjukvård
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- Mellgren, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska Academy,Department of Pediatric Oncology, Institute of Clinical Sciences, University of Gothenburg
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- Toporski, Jacek (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Pediatric Oncology and Hematology, University of Lund
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- Winiarski, J. (author)
- Karolinska Institutet,Karolinska Institute,Department of Pediatrics, Astrid Lindgren’s Children’s Hospital, Karolinska University Hospital
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- Ljungman, Gustaf, 1958- (author)
- Uppsala universitet,Uppsala University,Barnneurologi/Barnonkologi
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von Essen, Johan (author)
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(creator_code:org_t)
- 2020-01-28
- 2020
- English.
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In: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339.
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Abstract
Subject headings
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- Purpose To evaluate the feasibility of oral cryotherapy (OC) in children and to investigate if OC reduces the incidence of severe oral mucositis (OM), oral pain, and opioid use in children undergoing hematopoietic stem cell transplantation (HSCT). Methods Fifty-three children, 4-17 years old, scheduled for HSCT in Sweden were included and randomized to OC or control using a computer-generated list. OC instructions were to cool the mouth with ice for as long as possible during chemotherapy infusions with an intended time of >= 30 min. Feasibility criteria in the OC group were as follows: (1) compliance >= 70%; (2) considerable discomfort during OC < 20%; (3) no serious adverse events; and (4) ice administered to all children. Grade of OM and oral pain was recorded daily using the WHO-Oral Toxicity Scale (WHO-OTS), Children's International Oral Mucositis Evaluation Scale, and Numerical Rating Scale. Use of opioids was collected from the medical records. Results Forty-nine children (mean age 10.5 years) were included in analysis (OC = 26, control = 23). The feasibility criteria were not met. Compliance was poor, especially for the younger children, and only 15 children (58%) used OC as instructed. Severe OM (WHO-OTS >= 3) was recorded in 26 children (OC = 15, control = 11). OC did not reduce the incidence of severe OM, oral pain, or opioid use. Conclusion The feasibility criteria were not met, and the RCT could not show that OC reduces the incidence of severe OM, oral pain, or opioid use in pediatric patients treated with a variety of conditioning regimens for HSCT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- Oral mucositis
- Children
- Hematopoietic stem cell transplantation
- Oral
- cryotherapy
- Feasibility
- evaluation scale chimes
- content validity
- cancer
- understandability
- perspectives
- chemotherapy
- prophylaxis
- guidelines
- management
- therapy
- Oncology
- Health Care Sciences & Services
- Rehabilitation
- Oral cryotherapy
- Oral mucositis
- Pediatrik
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kamsvåg, Tove, 1 ...
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Svanberg, Anncar ...
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Legert, K. G.
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Arvidson, Johan, ...
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von Essen, Louis ...
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Mellgren, Karin, ...
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show more...
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Toporski, Jacek
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Winiarski, J.
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Ljungman, Gustaf ...
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von Essen, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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MEDICAL AND HEAL ...
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and Health Sciences
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Supportive Care ...
- By the university
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University of Gothenburg
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Lund University
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna