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Sökning: L773:0007 0920 OR L773:1532 1827 > Prognostic nomogram...

Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP)

Vernerey, Dewi (författare)
Univ Hosp Besancon, Methodol & Qual Life Oncol Unit, EA 3181, 3 Blvd Alexandre Fleming, F-25030 Besancon, France.
Huguet, Florence (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Tenon Hosp, AP HP, Dept Radiotherapy, 4 Rue Chine, F-75020 Paris, France.
Vienot, Angelique (författare)
Univ Hosp Besancon, Dept Gastroenterol, 3 Blvd Alexandre Fleming, F-25030 Besancon, France.
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Goldstein, David (författare)
Prince Wales Hosp, Dept Med Oncol, Sydney, NSW 2031, Australia.;UNSW, Prince Wales Clin Sch, Sydney, NSW 2031, Australia.;AGITG Australasian Gastrointestinal Trials Grp, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.
Paget-Bailly, Sophie (författare)
Univ Hosp Besancon, Methodol & Qual Life Oncol Unit, EA 3181, 3 Blvd Alexandre Fleming, F-25030 Besancon, France.
Van Laethem, Jean-Luc (författare)
Erasme Univ Hosp, Dept Gastroenterol, Route Lennik 808, B-1070 Brussels, Belgium.
Glimelius, Bengt (författare)
Uppsala universitet,Experimentell och klinisk onkologi
Artru, Pascal (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Jean Mermoz Hosp, Dept Gastroenterol, 55 Ave Mermoz, F-69008 Lyon, France.
Moore, Malcolm J. (författare)
Princess Margaret Hosp, Dept Med Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
Andre, Thierry (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;St Antoine Hosp, AP HP, Dept Med Oncol, 184 Rue Faubourg St Antoine, F-75011 Paris, France.
Mineur, Laurent (författare)
St Catherine Inst, Dept Radiotherapy & Med Oncol, 250 Chemin Baigne Pieds, F-84918 Avignon, France.
Chibaudel, Benoist (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Franco British Hosp Inst, Dept Med Oncol, 3 Rue Barbes, F-92300 Levallois Perret, France.
Benetkiewicz, Magdalena (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.
Louvet, Christophe (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Inst Mutualiste Montsouris, Dept Med Oncol, 42 Blvd Jourdan, F-75014 Paris, France.
Hammel, Pascal (författare)
Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Beaujon Hosp, AP HP, Dept Digest Oncol, 100 Blvd Gen Leclerc, F-92110 Clichy, France.
Bonnetain, Franck (författare)
Univ Hosp Besancon, Methodol & Qual Life Oncol Unit, EA 3181, 3 Blvd Alexandre Fleming, F-25030 Besancon, France.;Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.
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Univ Hosp Besancon, Methodol & Qual Life Oncol Unit, EA 3181, 3 Blvd Alexandre Fleming, F-25030 Besancon, France Oncol Multidisciplinary Res Grp GERCOR, 151 Rue Faubourg St Antoine, F-75011 Paris, France.;Tenon Hosp, AP HP, Dept Radiotherapy, 4 Rue Chine, F-75020 Paris, France. (creator_code:org_t)
2016-07-12
2016
Engelska.
Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 115:3, s. 281-289
Relaterad länk:
https://www.nature.c...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better discrimination for overall survival (OS) at diagnosis is needed. We address this issue by developing and validating a prognostic nomogram and a score for OS in LAPC (PROLAP).Methods: Analyses were derived from 442 LAPC patients enrolled in the LAP07 trial. The prognostic ability of 30 baseline parameters was evaluated using univariate and multivariate Cox regression analyses. Performance assessment and internal validation of the final model were done with Harrell's C-index, calibration plot and bootstrap sample procedures. On the basis of the final model, a prognostic nomogram and a score were developed, and externally validated in 106 consecutive LAPC patients treated in Besanc, on Hospital, France.Results: Age, pain, tumour size, albumin and CA 19-9 were independent prognostic factors for OS. The final model had good calibration, acceptable discrimination (C-index = 0.60) and robust internal validity. The PROLAP score has the potential to delineate three different prognosis groups with median OS of 15.4, 11.7 and 8.5 months (log-rank P<0.0001). The score ability to discriminate OS was externally confirmed in 63 (59%) patients with complete clinical data derived from a data set of 106 consecutive LAPC patients; median OS of 18.3, 14.1 and 7.6 months for the three groups (log-rank P<0.0001).Conclusions: The PROLAP nomogram and score can accurately predict OS before initiation of induction chemotherapy in LAPC-untreated patients. They may help to optimise clinical trials design and might offer the opportunity to define risk-adapted strategies for LAPC management in the future.

Nyckelord

prognostic score
nomogram
overall survival
locally advanced pancreatic cancer
chemotherapy

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