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Prognostic utility ...
Prognostic utility of HOXB13:IL17BR and Molecular Grade Index in early-stage breast cancer patients from the Stockholm trial
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- Jerevall, Piiha-Lotta (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Ma, Xiai-Jun (författare)
- bioTheranostics, San Diego, CA, USA
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- Li, Hongying (författare)
- bioTheranostics, San Diego, CA, USA
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- Salunga, Ranelle (författare)
- Massachusetts General Hospital, USA
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- Kesty, Nicole C. (författare)
- bioTheranostics, 9640 Towne Centre Dr Suite 200, San Diego, CA 92121, USA
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- Erlander, Mark G. (författare)
- Karolinska Institute, Stockholm, Sweden
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- Sgroi, Dennis (författare)
- Harvard Medical School, Boston, MA, USA
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- Holmlund, Birgitta (författare)
- Karolinska Institute, Stockholm, Sweden
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- Skoog, Lambert (författare)
- Karolinska Institutet
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- Fornander, Tommy (författare)
- Karolinska Institutet
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- Nordenskjöld, Bo (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Stål, Olle (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- 2011-05-10
- 2011
- Engelska.
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Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 104:11, s. 1762-1769
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: A dichotomous index combining two gene expression assays, HOXB13:IL17BR (H:I) and molecular grade index (MGI), was developed to assess risk of recurrence in breast cancer patients. The study objective was to demonstrate the prognostic utility of the combined index in early-stage breast cancer. Methods: In a blinded retrospective analysis of 588 ER-positive tamoxifen-treated and untreated breast cancer patients from the randomized prospective Stockholm trial, H:I and MGI were measured using real-time RT-PCR. Association with patient outcome was evaluated by Kaplan-Meier analysis and Cox proportional hazard regression. A continuous risk index was developed using Cox modeling. Results: The dichotomous H:I+MGI was significantly associated with distant recurrence and breast cancer death. The >50% of tamoxifen-treated patients categorized as low-risk had <3% 10-year distant recurrence risk. A continuous risk model (Breast Cancer Index (BCI)) was developed with the tamoxifen-treated group and the prognostic performance tested in the untreated group was 53% of patients categorized as low-risk with an 8.3% 10-year distant recurrence risk. Conclusion: Retrospective analysis of this randomized, prospective trial cohort validated the prognostic utility of H:I+MGI and was used to develop and test a continuous risk model that enables prediction of distant recurrence risk at the patient level.
Nyckelord
- Breast Cancer Index
- recurrence
- risk assessment
- gene expression profiling
- prognosis
- MEDICINE
- MEDICIN
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Jerevall, Piiha- ...
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Ma, Xiai-Jun
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Li, Hongying
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Salunga, Ranelle
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Kesty, Nicole C.
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Erlander, Mark G ...
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visa fler...
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Sgroi, Dennis
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Holmlund, Birgit ...
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Skoog, Lambert
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Fornander, Tommy
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Nordenskjöld, Bo
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Stål, Olle
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visa färre...
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Linköpings universitet
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Karolinska Institutet