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Exposure to polychl...
Exposure to polychlorinated biphenyls and prostate cancer : population-based prospective cohort and experimental studies
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- Ali, Imran (författare)
- Karolinska Institutet
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- Julin, Bettina (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.
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- Glynn, Anders (författare)
- The National Food Agency, Uppsala, Sweden,Natl Food Agcy, SE-75126 Uppsala, Sweden.
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- Högberg, Johan (författare)
- Karolinska Institutet
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- Berglund, Marika (författare)
- Karolinska Institutet
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- Johansson, Jan-Erik (författare)
- School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Urology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden.;Orebro Univ Hosp, Dept Urol, SE-70185 Orebro, Sweden.
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- Andersson, Swen-Olof, 1949- (författare)
- School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Urology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden.;Orebro Univ Hosp, Dept Urol, SE-70185 Orebro, Sweden.
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- Andrén, Ove, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden.;Orebro Univ Hosp, Dept Urol, SE-70185 Orebro, Sweden.
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- Giovannucci, Edward (författare)
- Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston MA, United States; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, United States,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Stenius, Ulla (författare)
- Karolinska Institutet
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- Åkesson, Agneta (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.
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, ring (författare)
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(creator_code:org_t)
- 2016-10-07
- 2016
- Engelska.
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Ingår i: Carcinogenesis. - : Oxford University Press. - 0143-3334 .- 1460-2180. ; 37:12, s. 1144-1151
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Polychlorinated biphenyls (PCBs) are highly persistent environmental pollutants and are undesirable components of our daily food. PCBs are classified as human carcinogens, but the evidence for prostate cancer is limited and available data are inconsistent. We explored the link between non-dioxin-like PCB and grade of prostate cancer in a prospective cohort as well as in cell experiments. A population-based cohort of 32496 Swedish men aged 45-79 years was followed prospectively through 1998-2011, to assess the association between validated estimates of dietary PCB exposure and incidence of prostate cancer by grade (2789 cases, whereof 1276 low grade, 756 intermediate grade, 450 high grade) and prostate cancer mortality (357 fatal cases). In addition, we investigated a non-dioxin-like PCB153-induced cell invasion and related markers in normal prostate stem cells (WPE-stem) and in three different prostate cancer cell lines (PC3, DU145 and 22RV1) at exposure levels relevant to humans. After multivariable-adjustment, dietary PCB exposure was positively associated with high-grade prostate cancer, relative risk (RR) 1.35 [95% confidence interval (CI): 1.03-1.76] and with fatal prostate cancer, RR 1.43 (95% CI: 1.05-1.95), comparing the highest tertile with the lowest. We observed no association with low or intermediate grade of prostate cancer. Cell invasion and related markers, including MMP9, MMP2, Slug and Snail, were significantly increased in human prostate cancer cells as well as in prostate stem cells after exposure to PCB153. Our findings both from the observational and experimental studies suggest a role of non-dioxin-like PCB153 in the development of high-grade and fatal prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Diet
- sem cells
- polychlorinated biphenyls
- prostate
- prostate cancer
- experimental study
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Till lärosätets databas
- Av författaren/redakt...
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Ali, Imran
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Julin, Bettina
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Glynn, Anders
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Högberg, Johan
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Berglund, Marika
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Johansson, Jan-E ...
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visa fler...
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Andersson, Swen- ...
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Andrén, Ove, 196 ...
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Giovannucci, Edw ...
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Wolk, Alicja
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Stenius, Ulla
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Åkesson, Agneta
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, ring
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Cell och molekyl ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Carcinogenesis
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet